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Substituted Urea



Substituted urea also known as hydroxyurea is used in combination with other medicines to treat chronic myelogenous leukemia (a type of blood cancer), cervical cancer and cancers of the head or neck region. It is also used to reduce the need for blood transfusions in patients with sickle cell anemia.

How it works

Substituted urea belongs to a class of drugs called as antimetabolites. It works by inhibiting cancer cell multiplication thus stopping the growth of cancer cells in the body. It also prevents the formation of sickle-shaped blood cells in patients with sickle cell anemia.

Common side effects

Shortness of breath, Nausea, Pancreatic inflammation, Liver enzyme increased, Irritation of ear, Allergic skin rash, Bleeding, Bruise, Chills, Constipation, Convulsion, Decrease in red blood cell count, Decreased sperm count, Decreased white blood cell count, Gastric ulcer, Hallucination, Indigestion, Abdominal pain, Loss of appetite, Feeling of discomfort, Muscle pain, Back pain, Reduced blood platelets, Vomiting, Diarrhoea


No medicine available

Expert advice

  • Inform your doctor if you have liver or kidney problems or if you suffered from gout (joint pain) in the past.
  • Inform your doctor if you are undergoing radiotherapy or chemotherapy (taking medicines to treat cancer) for cancer.
  • Wear protective clothing or apply sunscreen while going out in the sun to prevent the risk of skin cancers during treatment with hydroxyurea.
  • Use effective birth control measures during treatment and up to 30 days (for females) or 1 year (for males) after stopping the treatment of substituted urea.
  • Do not drive or use any machinery after taking substituted urea as it may cause dizziness.
  • Do not consume alcohol when on treatment with substituted urea, as it may worsen its side effects.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding. 
  • Do not take if patient is allergic to hydroxyurea or any of its ingredients.
  • Do not take if patient with the history of blood problems or severe anemia (deficiency of red blood cells and hemoglobin in the blood).

Frequently asked questions

Substituted Urea


Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)