Substituted Urea

Information about Substituted Urea

Substituted Urea Uses

Substituted Urea is used in the treatment of sickle cell anemia, prostate cancer, blood cancer (acute lymphocytic leukemia), soft tissue sarcoma and Hodgkin’s disease.

How Substituted Urea works

Substituted urea belongs to a class of drugs called as antimetabolites. It works by inhibiting cancer cell multiplication thus stopping the growth of cancer cells in the body. It also prevents the formation of sickle-shaped blood cells in patients with sickle cell anemia.

Common side effects of Substituted Urea

Breathlessness, Low blood platelets, Rash, Irritation of ear, Headache, Dizziness, Angioedema (swelling of deeper layers of skin), Injection site pain, Convulsion, Back pain, Edema (swelling), Increased heart rate, Oligospermia (low sperm count), Muscle pain, Pancreatic inflammation, Breast enlargement in male, Vomiting, Weakness, Allergic skin rash, Nausea, Decreased potassium level in blood, Abdominal pain, Indigestion, Loss of appetite, Decreased white blood cell count, Paresthesia (tingling or pricking sensation), Decreased red blood cell count, Fatigue, Increased liver enzymes, Fever, Anemia (low number of red blood cells), Hallucination, Itching, Bleeding, Chills, Urinary tract infection, Diarrhea, Increased creatine phosphokinase (CPK) level in blood, High blood pressure, Burning sensation, Decreased appetite, Feeling of discomfort, Megaloblastic anemia, Mucosal inflammation, Flushing (sense of warmth in the face, ears, neck and trunk), Low albumin level in blood, Hives, Decreased white blood cell count (neutrophils), Bruise, Constipation, Stomatitis (Inflammation of the mouth), Azoospermia (absence of sperms), Stomach ulcer, Increased glucose level in blood, Decreased blood pressure
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Written By
MMST, MBBS
Last updated
23 May 2025 | 07:19 PM (UTC)

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Available Medicine for Substituted Urea

Expert advice for Substituted Urea

  • Inform your doctor if you have liver or kidney problems or if you suffered from gout (joint pain) in the past.
  • Inform your doctor if you are undergoing radiotherapy or chemotherapy (taking medicines to treat cancer) for cancer.
  • Wear protective clothing or apply sunscreen while going out in the sun to prevent the risk of skin cancers during treatment with hydroxyurea.
  • Use effective birth control measures during treatment and up to 30 days (for females) or 1 year (for males) after stopping the treatment of substituted urea.
  • Do not drive or use any machinery after taking substituted urea as it may cause dizziness.
  • Do not consume alcohol when on treatment with substituted urea, as it may worsen its side effects.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding. 
  • Do not take if patient is allergic to hydroxyurea or any of its ingredients.
  • Do not take if patient with the history of blood problems or severe anemia (deficiency of red blood cells and hemoglobin in the blood).
 

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