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Ropinirole is used to treat moderate to severe restless legs syndrome (crawling or bubbling sensation causing irresistible leg movements) of unknown origin.

How it works

Ropinirole acts in specific areas of brain to stimulate proteins called dopamine receptors, and relieves the unpleasant sensation thereby reducing the urge to move the legs and other limbs.

Common side effects

Vomiting, Nausea, Altered libido, Memory loss, Anxiety, Constipation, Diarrhoea, Abdominal pain, Dizziness, Drowsiness, Headache, Impaired concentration, Loss of appetite, Uncoordinated body movements, Weight loss


Expert advice

  • Do not use ropinirole, if you are allergic (hypersensitive) to ropinirole or any of the ingredients in the medicine.
  • Patient taking ropinirole are advised to exercise caution while driving or operating machines as it can cause excessive sleepiness.
  • Avoid taking ropinirole if you are pregnant, planning to become pregnant, or breastfeeding.
  • Do not take ropinirole, if you have severe heart problems; serious mental health problem; experienced unusual urges (like excessive sexual behavior or gambling etc.); undergoing hormone replacement therapy.

Frequently asked questions


Q. Is ropinirole a controlled substance or addictive?
Ropinirole doesn’t seem to have habit forming potential. It belongs to schedule H and is not controlled substance in India.
Q. Is ropinirole a mono amine oxidase inhibitor (MAOI)/opiate/ narcotic/ pain killer/ muscle relaxer?
Ropinirole is not a mono amine oxidase inhibitor (MAOI) or opiate narcotic or pain killer or muscle relaxer. It has dopamine stimulant action and acts to stop urge to move limbs unnecessarily.
Q. Is ropinirole safe?
Ropinirole is safe when taken at prescribed dose and duration as advised by your doctor.
Q. Can I take Requip (ropinirole) with Ambien (Zolpidem)/ tramadol/ Vicodin (hydrocodone)/ ibuprofen/ Benadryl?
Using Ambien (zolpidem) or Benadryl (diphenhydramine) or Vicodin (acetaminophen / hydrocodone) or tramadol together with Requip (ropinirole) may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Ibuprofen when taken with Requip (ropinirole) doesn’t seem to produce any interactions.
Q. Does ropinirole cause weight gain/ constipation/ dry mouth/ sleepiness/ lower pain/ get you high?
Ropinirole may cause sleepiness but it doesn’t cause weight gain, constipation and dry mouth. It doesn’t seem to lower pain to get person high.

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)