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Prothionamide is used in the treatment of tuberculosis (tb)

How it works

Prothionamide is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.

Common side effects

Loss of appetite, Nausea, Vomiting, Gastric irritation, Orthostatic hypotension (sudden lowering of blood pressure on standing), Depression, Weakness, Sleepiness

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Expert advice

• Prothionamide is not recommended in children under 14 years of age.
• Tell your doctor before taking prothionamide if you have or had diabetes, fits, depression, other mental illness, severe kidney disease, liver problems, or vision problems.
• Take precautions if you have a history of mental disorders as prothionamide may cause excitability.
• You may be monitored with blood tests for changes in levels of blood sugar, liver function, and thyroid function tests and examination of vision, while on treatment with prothionamide.
• Do not consume alcohol during prothionamide therapy as it may worsen the side effects.
• Should not be given to patients allergic to prothionamide or any of its ingredients.
• Should not be given to patients with stomach and / or duodenal ulcer,  diseases of the gut causing recurrent ulcers in the gut, abdominal pain, recurrent diarrhea/ dysentery, (ulcerative colitis).
• Should not be given to pregnant and breastfeeding women.
• Should not be administered to patients with severe liver disease.
• Should not be given to patients with alcohol dependence.

Content on this page was last updated on 16 March, 2017, by Dr. Varun Gupta (MD Pharmacology)