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Prothionamide is used in the treatment of tuberculosis (TB).

How it works

Prothionamide belongs to class of drugs called anti-tuberculosis agents. It blocks mycolic acid synthesis, a substance necessary to maintain the integrity of the cell wall of Mycobacterium tuberculosis and thus results in death of infection causing microorganism.

Common side effects

Nausea, Liver enzyme increased, Dizziness, Increased bilirubin in the blood, Increased saliva production, Loss of appetite, Restlessness


Expert advice

• Prothionamide is not recommended in children under 14 years of age.
• Tell your doctor before taking prothionamide if you have or had diabetes, fits, depression, other mental illness, severe kidney disease, liver problems, or vision problems.
• Take precautions if you have a history of mental disorders as prothionamide may cause excitability.
• You may be monitored with blood tests for changes in levels of blood sugar, liver function, and thyroid function tests and examination of vision, while on treatment with prothionamide.
• Do not consume alcohol during prothionamide therapy as it may worsen the side effects.
• Should not be given to patients allergic to prothionamide or any of its ingredients.
• Should not be given to patients with stomach and / or duodenal ulcer,  diseases of the gut causing recurrent ulcers in the gut, abdominal pain, recurrent diarrhea/ dysentery, (ulcerative colitis).
• Should not be given to pregnant and breastfeeding women.
• Should not be administered to patients with severe liver disease.
• Should not be given to patients with alcohol dependence.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)