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    Information about Procyclidine

    Procyclidine uses

    Procyclidine is used in Parkinson's disease.

    How procyclidine works

    Procyclidine is a muscle relaxing medication. It works by decreasing the activity of excess acetylcholine in the brain. This improves muscle control and reduces stiffness. It helps patients with Parkinson's disease by improving muscle control and reducing stiffness so that they can move more naturally. It is also used to treat movement disorder (restlessness, involuntary movements or muscle spasm ) which can be caused by certain drugs.

    Common side effects of procyclidine

    Dryness in mouth, Nausea, Vomiting, Constipation, Blurred vision, Dizziness, Lightheadedness, Dilatation of pupil, Epigastric pain, Urinary retention
    Content Details
    Written By
    Dr. Swati Mishra
    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    27 Dec 2019 | 01:08 PM (IST)
    Want to know more?
    Read Our Editorial Policy

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    Expert advice for Procyclidine

    • Procyclidine helps treat Parkinson's disease and drug-induced abnormal movements.
    • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
    • It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
    • It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
    • Inform your doctor if you suffer from  glaucoma or if you have trouble passing urine.
    • Do not stop taking Procyclidine without talking  to your doctor first as that may cause worsening of symptoms.
    • Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
    • You may be asked for regular monitoring of hypotension,  kidney, liver, and cardiac disorder while taking this medicine. 

    Frequently asked questions for Procyclidine


    Q. How long does Procyclidine take to work?

    After an hour of starting Procyclidine most people start experiencing the effects. However, the medicine may take some time for showing full benefits. Consult your doctor if you do not see improvement.

    Q. Can I take Procyclidine for excessive salivation?

    Yes, Procyclidine can be used as it is helpful in cases of excessive salivation and drooling which can be seen in Parkinson’s disease or due to medicines (neuroleptics). It should be taken only if prescribed by your doctor.

    Q. Can Procyclidine cause addiction?

    Yes, Procyclidine may cause addiction as it has abuse potential though it occurs rarely. The doctors are usually cautious while prescribing this medicine and do not prescribe this medicine to patients whose symptoms are not genuine.

    Q. What should I avoid while taking Procyclidine?

    Avoid driving or operating machines if Procyclidine causes blurred vision or makes you feel dizzy, confused or disorientated. You should also avoid taking alcohol as it may increase your drowsiness. Taking this medicine may affect your body’s ability to regulate its temperature. As a result, your body temperature may rise more than normal. So, you should also avoid areas with high humidity and high temperature.

    Q. Who should not take Procyclidine?

    Patients who are allergic to Procyclidine or any of the other ingredients of this medicine should not take Procyclidine. This medicine should be avoided in cases of glaucoma (increased pressure in the eye) in patients who have a blockage in the intestine (gut). In addition, patients who are facing difficulty, or are unable to, pass urine and are not currently receiving any form of treatment for this, should avoid taking Procyclidine.

    Q. How can I identify overdose symptoms?

    In case of an overdose, you may experience fast heartbeat, agitation, restlessness, confusion, insomnia (severe inability to sleep), excitement (although occasionally people may feel anxious and aggressive), and disorientation. If eyes are exposed to light then the pupils in the eye may not open or close and hallucinations (seeing or hearing things that are not real) may also occur. In severe cases, you may feel very sleepy, fall into unconsciousness, or into a coma. If you experience any such symptoms contact your doctor or seek immediate help from the nearest hospital emergency department.

    Q. Can I stop taking Procyclidine?

    No, you should not stop taking Procyclidine suddenly as rebound parkinsonian symptoms may occur. Take the medicine as long as symptoms are there. Your doctor will decide the probable duration required for the medicine.

    Content on this page was last updated on 27 December, 2019, by Dr. Varun Gupta (MD Pharmacology)