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    Pregabalin + Nortriptyline + Methylcobalamin/Mecobalamin

    Information about Pregabalin + Nortriptyline + Methylcobalamin/Mecobalamin

    Pregabalin + nortriptyline + methylcobalamin/mecobalamin uses

    Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin is used in the treatment of neuropathic pain.

    How pregabalin + nortriptyline + methylcobalamin/mecobalamin works

    This is a combination of three medicines: Pregabalin, Nortriptyline and Methylcobalamin/Mecobalamin. Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin/Mecobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

    Common side effects of pregabalin + nortriptyline + methylcobalamin/mecobalamin

    Constipation, Weight gain, Orthostatic hypotension (sudden lowering of blood pressure on standing), Increased heart rate, Dizziness, Sleepiness, Tiredness, Blurred vision, Dryness in mouth, Difficulty in urination, Uncoordinated body movements
    Content Details
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    Written By
    Dr. Anuj Saini
    MMST, MBBS
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    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    27 Nov 2018 | 05:07 PM (IST)
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    Available Medicine for Pregabalin + Nortriptyline + Methylcobalamin/Mecobalamin

    Frequently asked questions for Pregabalin + Nortriptyline + Methylcobalamin/Mecobalamin

    Pregabalin + Nortriptyline + Methylcobalamin/Mecobalamin

    Q. What is Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin?

    Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin is a combination of three medicines: Gabapentin, Nortriptyline and Methylcobalamin. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

    Q. Can I stop taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin when my pain is relieved?

    No, you should not stop taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.

    Q. How to manage weight gain associated with the use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin?

    Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.

    Q. Can the use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin cause sleepiness or drowsiness?

    Yes, Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights, or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.

    Q. Can the use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin affect my sexual life?

    The use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin can affect the sexual life of both men and women. Most commonly observed problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while intercourse. If you experience these problems, discuss them with your doctor but do not stop taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin.

    Q. Are there any serious side effects associated with the use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin?

    Serious side effects because of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin are uncommon and rare. Consult your doctor if you notice any of the following: changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior (such as restlessness, nervousness or excitement), signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and need urgent medical attention.

    Q. How long will Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin take to act?

    An initial benefit with Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin may be seen after 2 weeks of the treatment. However, it may take around 2-3 months or more to see full benefits and even.

    Q. What if I forget to take Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin?

    If you forget to take the scheduled dose of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect. If you are not sure what to do, consult your about how to manage a situation like this.

    Q. What if I take too much of this drug by mistake?

    In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteadiness while walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heartbeat.

    Q. Will a higher than the recommended dose of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin be more effective?

    No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

    Q. Is there anything I need to avoid while taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin?

    Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while you are taking Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.

    Q. How often should I see the doctor?

    You may need to see your doctor regularly if you have started to take Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin. However, you must consult your doctor if the advised dosage of Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin does not improve your symptoms or you continue experiencing some unwanted side effects that affect your routine activities.

    Q. Are there any special instructions regarding storage and disposal of this medicine?

    Keep your tablets in the pack until it is time to take them. Store them in a cool dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

    Q. Does Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin expire?

    Yes, Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin does expire. Please check the expiry date written on the pack of this medicine. Do not use Pregabalin+Nortriptyline+Methylcobalamin/Mecobalamin after the expiry date.

    Content on this page was last updated on 27 November, 2018, by Dr. Varun Gupta (MD Pharmacology)