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Piperaquine is used in combination with other anti-malarial drugs to treat uncomplicated malaria caused by a parasite Plasmodium falciparum, spread by infected mosquito bite.

How it works

Piperaquine belongs to a class of drugs called bisquinoline anti-malarial. It acts by killing the parasite with its own chemical waste produced during infection.

Common side effects

Palpitations, Altered heart rate, Cough, Shortness of breath, Nausea, Vomiting, Weakness


Expert advice

  • Take piperaquine on empty stomach with water only. It should be taken 3 hours after the food intake and no food to be eaten within 3 hours after each dose.
  • Always take piperaquine continuously for 3 days as recommended by your doctor. 
  • Exercise caution while taking piperaquine if you are an elderly patient.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • Patients allergic to piperaquine or any of its ingredients.
  • Do not give if Children is below 6 months or weight below 5 kg.
  • Avoid if Patient is suffering from severe malaria affecting brain, lungs or kidneys.
  • Avoid if Malaria infection caused by a parasite other than Plasmodium falciparum.
  • Avoid if Patient is suffering from heart condition, such as changes to the rhythm or rate of heart beat, or any heart disease or any of family members having heart complaints.
  • Do not take if suffering from salt imbalance.
  • Avoid if Patient is treated with malarial medicines or for prevention of malaria within 1 month.
  • Avoid if Patient is on treatment for bacterial infection, fungal infection, allergy, stomach complaints, drug addiction, high cholesterol, certain cancers, depression, or any mental disorders.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)