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    Information about Pamidronate

    Pamidronate uses

    Pamidronate is used in the treatment of high calcium levels in the blood.

    How pamidronate works

    Pamidronate is a bisphosphonate. It acts by suppressing the activity of osteoclasts, cells that cause the destruction of bone, thereby strengthening the bones and minimizing the risk of fractures.

    Common side effects of pamidronate

    Headache, Back pain, Musculoskeletal (bone, muscle or joint) pain, Indigestion, Heartburn, Diarrhea
    Content Details
    Written By
    Dr. Radhika Dua
    MDS, BDS
    Reviewed By
    Dr. Shilpa Garcha
    MD (Pharmacology), MBBS
    Last updated on:
    11 Nov 2019 | 05:32 PM (IST)
    Want to know more?
    Read Our Editorial Policy

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    Expert advice for Pamidronate

    • Your doctor has prescribed Pamidronate to make your bones stronger and lower the risk of fractures.
    • Take it in the morning at least 30 minutes before eating or drinking anything.
    • Maintain an upright posture for 30 minutes after taking the medication so the medicine does not irritate your food pipe.
    • It may cause the amount of calcium in your blood to fall. Take calcium-rich food in your diet and have regular blood tests to monitor the level of calcium in your blood.
    • It is important to look after your mouth and teeth while you are taking this medicine. Have regular dental check-ups and inform your dentist about taking Pamidronate.
    • It is given by injection into a vein, usually over at least 15 minutes or as directed by your doctor.
    • Drink plenty of fluids to prevent dehydration and kidney damage.
    • It can lower the level of calcium in the blood. Take calcium and vitamin D supplements as suggested by your doctor.
    • You may develop fever or flu like symptoms, such as chills, tiredness and weakness. These are usually temporary and should go away after a few days. You may take a pain reliever/fever reducer to prevent or treat these symptoms.
    • It may cause a rare condition called osteonecrosis of the jaw. Have regular dental check-ups and inform your doctor if you develop sudden pain in your jaw.
    • Your doctor will monitor your response to Pamidronate by testing your bone mineral density (BMD). This is usually done every 1-3 years.
    • Do not take it if you are pregnant or breastfeeding.

    Frequently asked questions for Pamidronate


    Q. How does Pamidronate work?

    Pamidronate works by decreasing the level of calcium released into the blood by bones, thereby preventing calcium excess in the body

    Q. Is Pamidronate safe?

    Yes. Pamidronate is safe if used at prescribed doses for the prescribed duration as advised by your doctor. In case of any side-effects, please consult your doctor.

    Content on this page was last updated on 11 November, 2019, by Dr. Varun Gupta (MD Pharmacology)