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Nattokinase is used to treat cardiovascular diseases including heart disease, high blood pressure, stroke, angina (chest pain), deep vein thrombosis (DVT), atherosclerosis (hardening of the arteries), hemorrhoids (a swollen vein or group of veins in the region of the anus), varicose veins (enlarged veins), poor circulation, and peripheral artery disease (circulatory problem in which narrowed arteries reduce blood flow to the limbs). It is also used for treating pain, fibromyalgia (widespread musculoskeletal pain), chronic fatigue syndrome, endometriosis (outgrowth of endometrial tissue outside the womb), uterine fibroids (non-cancerous growth that develops in the muscular wall of the uterus), muscle spasms, infertility, cancer and a vitamin B1-deficiency disease called beriberi.

How it works

Nattokinase belongs to the class of medications called as fibrinolytic agents. It acts by decreasing the ability of blood to clot thereby preventing the conditions caused by blood clots such as stroke, heart attack, and others related diseases.

Common side effects

Flushing, Gastrointestinal disturbance, Decreased white blood cell count


Expert advice

  • Avoid activities that may cause high risk of injury, bruising or bleeding as nattokinase decreases clotting of the blood.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
  • Do not take if allergic to nattokinase or any of its ingredients.
  • Do not take if suffering with ischemic stroke, peptic ulcer, and coagulation disorders and with concomitant anticoagulant therapy.
  • Do not take if scheduled for surgery in the next two weeks.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)