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Methyldopa is used in the treatment of increased blood pressure .

How it works

Methyldopa belongs to a group of medicines called antihypertensives. It reduces elevated blood pressure by relaxing and dilating (widening) blood vessels.

Common side effects

Nightmare, Depression, Paralysis, Abdominal bloating, Abdominal pain, Abnormal blood test, Abnormal production of milk, Absence of menstrual periods, Decreased red blood cell count, Anemia, Abnormal breast enlargement in male, Bruise, Bleeding time prolongation, Confusion, Constipation, Diarrhoea, Dizziness, Lightheadedness, Decreased blood pressure, Fainting, Dry mouth, Flatulence, Weakness, Headache, Ejaculation disorder, Impotence, Muscle pain, Black tongue, Sore tongue, Swelling of salivary glands, Tingling sensation, Uncoordinated body movements, Vomiting, Water retention, Swelling, Weight gain


Expert advice

  • Do not take methyldopa if you ever had or have any allergy to methyldopa, or to any of the other ingredients.
  • Avoid taking methyldopa if you have high blood pressure due to a tumor near your kidney called ‘phaeochromocytoma’.
  • Do not take methyldopa if you have liver or kidney disease, or depression.
  • Do not take methyldopa if you are pregnant, planning to become pregnant or breast-feeding.
  • Do not drive or use any tools or machines as you may feel drowsy or light-headed while taking methyldopa. 
  • Do not drink alcohol while you are using methyldopa.
  • Methyldopa may affect the results of certain laboratory tests: regular checks (before the start of treatment and 6-12 weeks later) may be carried out on blood cells and liver function.

Frequently asked questions


Q.Is methyldopa a beta blocker/ blood thinner/ diuretic/ calcium channel blocker?
Methyldopa is an alpha-2 receptor agonist. It is not a beta blocker, blood thinner, diuretic or calcium channel blocker

Q.Can I take ibuprofen/ paracetamol/ aspirin/ melatonin with methyldopa?
Methyldopa is known to interact with NSAIDs such as ibuprofen, paracetamol, aspirin. However, there is no known interaction with melatonin. Always consult your doctor regarding its use

Q.Does methyldopa cause weight gain/ make you tired/ lower heart rate/ hair loss/ birth defects/ dry mouth/ swelling?
Methyldopa is known to cause tiredness, dry mouth and swelling. However it does not cause weight gain, lower heart rate, cause birth defects. Please consult your doctor if you experience such side effects.

Content on this page was last updated on 15 November, 2016, by Dr. Varun Gupta (MD Pharmacology)