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Metformin + Vildagliptin

Information about Metformin + Vildagliptin

How Metformin + Vildagliptin works

Metformin + Vildagliptin is a combination of two antidiabetic medicines: Metformin and Vildagliptin. Metformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Vildagliptin is a DPP-4 inhibitor which works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.

Common side effects of Metformin + Vildagliptin

Nausea, Dizziness, Headache, Hypoglycemia (low blood glucose level), Tremors, Weight gain
CONTENT DETAILS
Written By
Dr. Anuj Saini
MMST, MBBS
Reviewed By
Dr. Ashish Ranjan
MD (Pharmacology), MBBS
Last updated
04 Oct 2021 | 06:39 AM (UTC)

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Expert advice for Metformin + Vildagliptin

  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • Take it in addition to regular exercise and healthy diet to lower levels of blood sugar.
  • Take it with food to lower your chance of having an upset stomach.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metformin + Vildagliptin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your kidney and liver function before starting treatment and regularly thereafter. Inform your doctor if you develop symptoms such as abdominal pain, fatigue, loss of appetite, darkened urine or yellowing of the eyes or skin (jaundice).

Frequently asked questions for Metformin + Vildagliptin

Metformin + Vildagliptin

Q. Can the use of Metformin + Vildagliptin lead to hypoglycemia?

The use of Metformin + Vildagliptin does not usually cause hypoglycemia (low blood sugar level) alone. But it could occur if there is insufficient supplementation of calories while taking this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. The symptoms are more likely to be noticed if you miss or delay your food, drink alcohol, over-exercise or take any other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. It is recommended to always carry glucose tablets, honey or fruit juice with you.

Q. Can the use of Metformin + Vildagliptin cause nausea and vomiting?

Yes, the use of Metformin + Vildagliptin can cause nausea and vomiting. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to a doctor.

Q. Are there any specific contraindications associated with the use of Metformin + Vildagliptin?

The use of Metformin + Vildagliptin should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine is also considered to be harmful for patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.

Q. What is the storage condition for the Metformin + Vildagliptin?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. What is Metformin + Vildagliptin?

Metformin + Vildagliptin is a combination of two anti-diabetic drugs: Metformin and Vildagliptin. Metformin is an anti-diabetic medicine and belongs to the class of biguanides. It lowers the glucose production in the liver, delays glucose absorption from the intestines and increases the body's sensitivity to insulin. Vidagliptin inhibits the enzyme DPP4 inhibitor and increases the release of insulin from the pancreas. This combination is not advised for the patients below 18 years of age.

Q. Can the use of Metformin + Vildagliptin cause lactic acidosis?

Yes, the use of Metformin + Vildagliptin can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin-associated lactic acidosis). It is a very rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Metformin + Vildagliptin and immediately consult your doctor.

Q. Can the use of Metformin + Vildagliptin lead to Vitamin B12 deficiency?

Yes, the use of Metformin + Vildagliptin can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems.

Q. Is it safe to use Metformin + Vildagliptin?

Yes, it is safe to use Metformin + Vildagliptin if you take it for the prescribed duration and according to the dosage advised by the doctor. However, despite taking the prescribed dosage you might experience common side effects like nausea, diarrhea, vomiting, stomach upset, headache, nasal congestion, sore throat, respiratory tract infection, hypoglycemia (low blood sugar level) in combination with insulin or sulphonylurea. Inform your doctor if you experience any persistent problem while taking this medicine.

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