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    Metformin + Teneligliptin

    Information about Metformin + Teneligliptin

    Metformin + teneligliptin uses

    Metformin+Teneligliptin is used in the treatment of type 2 diabetes mellitus.

    How metformin + teneligliptin works

    This is a combination of two antidiabetic medicines: Metformin and Teneligliptin. Metformin is an antidiabetic medication (biguanide). It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Teneligliptin is a dipeptidyl peptidase-4 inhibitor which works by increasing the release of insulin from pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.

    Common side effects of metformin + teneligliptin

    Diarrhea, Nausea, Vomiting, Stomach upset, Headache, Nasal congestion, Sore throat, Respiratory tract infection, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
    Content Details
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    Written By
    Dr. Anuj Saini
    MMST, MBBS
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    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    14 May 2019 | 11:54 AM (IST)
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    Expert advice for Metformin + Teneligliptin

    • Take it with food to lower your chance of having an upset stomach.
    • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
    • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
    • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metformin + Teneligliptin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

    Frequently asked questions for Metformin + Teneligliptin

    Metformin + Teneligliptin

    Q. What is Metformin+Teneligliptin?

    Metformin+Teneligliptin is a combination of two medicines: Metformin and Teneligliptin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Teneligliptin inhibits the enzyme DP4 inhibitor and increases the release of insulin from the pancreas. This combination is not indicated for the patients below 18 years of age.

    Q. What are the possible side effects of Metformin+Teneligliptin?

    The use of Metformin+Teneligliptin is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious, but rare side effect like lactic acidosis. On long-term use it can also lead to vitamin B12 deficiency.

    Q. Are there any specific conditions in which Metformin+Teneligliptin should not be taken?

    The use of Metformin+Teneligliptin should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine is also considered to be harmful for patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.

    Q. Is it safe to take alcohol while I am also taking Metformin+Teneligliptin?

    No, it is not safe to take Metformin+Teneligliptin along with alcohol. It can increase the chances of lactic acidosis, particularly in cases of fasting, malnutrition or hepatic impairment.

    Q. Can the use of Metformin+Teneligliptin cause hypoglycemia?

    The use of Metformin+Teneligliptin does not usually cause hypoglycemia (low blood sugar level). However, hypoglycemia may occur if there is insufficient supplementation of calories while taking this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry glucose tablets, honey or fruit juice with you.

    Q. Can the use of Metformin+Teneligliptin lead to Vitamin B12 deficiency?

    Yes, the use of Metformin+Teneligliptin can cause vitamin B12 deficiency on long-term use as it interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

    Q. What are the instructions for the storage and disposal of Metformin+Teneligliptin?

    Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

    Content on this page was last updated on 14 May, 2019, by Dr. Varun Gupta (MD Pharmacology)