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Mesalazine Topical



Mesalazine also known as mesalamine, is topically used for the treatment and prevention of short episodes of ulcerative colitis (inflammatory disease of colon), Crohn’s ileocolitis (inflammation of lining of ileum and colon), proctosigmoiditis or proctitis (disease confined to rectum or lower intestine). It is also used to reduce bleeding, mucous and bloody diarrhea caused by inflammation (swelling and soreness) of the rectal area.

How it works

Mesalazine belongs to the class of medications called as salicylates. It acts locally on the intestinal lining to reduce the inflammation and prevents further swelling, ulcers or abscess (puss filled swelling) thereby relieving associated symptoms.

Common side effects

Vomiting, Nausea, Abdominal bloating, Abdominal pain, Diarrhoea, Headache, Rash, Itching, Rectal pain, Stomach pain


No medicine available

Expert advice

  • The enema should be used in the back passage (rectum) only.
  • Consult your doctor and discontinue use if you experience any unexplained bleeding, bruising, skin rashes, fever or sore throat, chest pain, an increased heartbeat and excess tiredness.
  • Inform your doctor if you get fever, severe itching or a rash or headache.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
  • Do not use if you are allergic to mesalazine or any of its ingredients.
  • Do not use if you have severe liver or kidney dysfunction. 
  • Do not use by Children.

Frequently asked questions

Mesalazine Topical

Q. Is mesalazine a steroid, NSAID, immunosuppressant, blood-thinner or sulfa drug?
Mesalazine is not a steroid, NSAID, immunosuppressant, blood-thinner or sulfa drug. It is an anti-inflammatory drug.
Q. Is mesalazine topical safe?
Yes. Mesalazine topical is relatively safe if used as recommended. In case of any side-effects, consult your doctor.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)