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Loxapine is used in adults to treat agitation due to schizophrenia (psychiatric or mental disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations and withdrawal into the self) and bipolar disorder (cyclical over excitation and depression).

How it works

Loxapine belongs to group of medicines called tricyclic antipsychotics. It alters the action of some chemicals in the body called serotonin and dopamine and decreases abnormal excitement in the brain.

Common side effects

Vomiting, Nausea, Excessive thirst, Agitation, Blurred vision, Constipation, Dizziness, Drowsiness, Dry mouth, Difficulty in urination, Headache, Increased saliva production, Insomnia, Slurred speech, Weakness, Weight gain, Weight loss


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Expert advice

  • Do not start or continue loxapine and consult your doctor if you have history of fits (seizures), heart or brain related diseases, respiratory or lung problems, or if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Do not drive or operate any machinery because you may feel sleepy or dizzy while being treated with loxapine.

Frequently asked questions


Q. Is loxapine or loxapine succinate an atypical antipsychotic or narcotic drug?
Loxapine or loxapine succinate is not an atypical antipsychotic or narcotic drug. It is a dibenzoxazepine typical antipsychotic.
Q. Does loxapine cause weight gain, diabetes, or tiredness?
Loxapine may cause weight gain or tiredness, but it is not known to cause diabetes.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)