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Loteprednol is used in the treatment of inflammatory and allergic conditions of the superficial layers of the eye, such as allergic conjunctivitis (allergic itching and redness of the whites of the eye, with tearing), conjunctivitis that occurs as part of acne rosacea (persistent redness over the areas of the face and nose), superficial punctate keratitis (inflammation of cornea), iritis (Inflammation of the interior eye structures), cyclitis (inflammation of cilliary body of the eye). It is also used in the treatment of postoperative inflammation of the eye after the eye surgery.

How it works

Loteprednol belongs to a class of medication called as ophthalmic corticosteroid. The exact mechanism of action is not known. They are thought to induce certain proteins (phospholipase A 2 inhibitory proteins) which inhibit the formation of other compounds like prostaglandin and leukotrienes which promote inflammation. As a result, the redness, swelling, and itching is relieved at the site of administration.

Common side effects

Burning sensation, Conjunctival redness, Conjuntival disorder, Corneal damage, Dry eye, Eye discharge, Eye irritation, Foreign body sensation in eyes, Headache, Increased production of tears, Itching


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Expert advice

  • Do not start or continue loteprednol if you have increased pressure inside the eyes that cause visual problem (glaucoma), pain, redness, itching or inflammation in eyes, or after a recent cataract surgery.
  • Avoid using for more than 10 days.
  • Avoid wearing contact lenses.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. What is loteprednol/loteprednol etabonate?
Loteprednol is a corticosteroid available as an eye drop that reduces inflammation of superficial structures of the eye.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)