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Lafutidine
INFORMATION ABOUT LAFUTIDINE
Lafutidine Uses
Lafutidine is used in the treatment of gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.
How Lafutidine works
Lafutidine blocks specific receptors (H2 receptors) on the lining of the stomach that stimulate acid production. It also increases the secretions (mucin) inside the stomach. This way, Lafutidine decreases acid production in the stomach and helps in healing the ulcers of the stomach and small intestine. Additionally, it reduces discomfort such as heartburn and gives relief from acid-related indigestion.
Common side effects of Lafutidine
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Nausea, Increased liver enzymes, Headache, Hallucination, Dizziness, Constipation, Diarrhea, Breast enlargement in male, Increased uric acid level in blood, Vomiting, Increased bilirubin in the blood, Decreased appetite
CONTENT DETAILS
Written By
Dr. Anuj Saini
MMST, MBBS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
11 Jun 2025 | 10:21 AM (UTC)
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Expert advice for Lafutidine
  • Take Lafutidine before going to bed if you are taking this medicine once a day. It is very effective in controlling stomach acid that is released when you are asleep.
  • If you are also taking other medications to treat acidity (e.g., antacid), take them 2 hours before or after taking Lafutidine.
  • Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
  • Inform your doctor if you do not feel better after taking Lafutidine for 2 weeks as you may be suffering from some other problems.
  • Inform your doctor if you have ever been diagnosed with kidney disease as dose of your medicine may need to be adjusted.
  • Do not stop taking the medication without talking to your doctor. 
  • Lafutidine is a well tolerated and safe medicine with a very low incidence of side effects.
  • Take it with or without food.
  • Take Lafutidine before going to bed if you are taking this medicine once a day. It is very effective in controlling stomach acid that is released when you are asleep.
  • If you are also taking other medications to treat acidity (e.g., antacid), take them 2 hours before or after taking Lafutidine.
  • Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
  • Inform your doctor if you do not feel better after taking Lafutidine for 2 weeks as you may be suffering from some other problems.
  • Inform your doctor if you have ever been diagnosed with kidney disease as dose of your medicine may need to be adjusted.
  • Do not stop taking the medication without talking to your doctor. 
Frequently asked questions for Lafutidine
Lafutidine may be taken with or without food. It can be taken once daily before bedtime or twice daily in the morning and before bedtime, as recommended.
If you take Lafutidine orally, the effect usually begins within one hour. The maximum effect is generally reached within one to three hours of taking it. However, it depends upon the dose. The action of the medicine lasts for about 10 to 12 hours.
Lafutidine and Omeprazole belong to different group of medicines. While Lafutidine belongs to histamine H2 antagonists group, Omeprazole belongs to proton pump inhibitors group. Both these medicines work by reducing the amount of acid made by the stomach to relieve the symptoms and allow healing.
Alcohol does not interfere with the working of Lafutidine. But, you should avoid taking alcohol as it will further damage the stomach, delaying your recovery.
Lafutidine may have some serious side effects but these are rare. These side effects may include hives, skin rash, itching, hoarseness and difficulty in breathing or swallowing. Another serious symptom may be swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs. Inform your doctor in case you notice any of the mentioned symptoms.
Avoid taking aspirin and other painkillers used to treat arthritis, period pain or headache. These medicines may irritate the stomach and make your condition worse. Contact your doctor who may suggest other medicines. Avoid coffee, tea, cocoa and cola drinks because these contain ingredients that may irritate your stomach. Eat smaller, more frequent meals. Eat slowly and chew your food carefully. Try not to rush at meal times. You should stop or cut down on smoking.
There is limited data available on whether Lafutidine can be used for a long term or not, but it is a relatively safe medicine. You should take it for the duration advised by your doctor. Do not take over-the-counter Lafutidine for longer than 2 weeks unless advised by your doctor.