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Isoleucine have anticatabolic and antitardive dyskinesia activity. It also used as a dietary supplement for patients with mapple syrup urine disorder.

How it works

The catabolism of isoleucine initiates in muscle and yields NADH and FADH2 which can be utilized for ATP generation. The catabolism of amino acids uses the same enzymes in the first two steps. The first step in each case is a transamination using a single BCAA aminotransferase, with a-ketoglutarate as amine acceptor. As a result, three different a-keto acids are produced and are oxidized using a common branched-chain a-keto acid dehydrogenase, yielding the three different CoA derivatives. Subsequently the metabolic pathways diverge, producing many intermediates.

Common side effects

Allergic reaction, Itching


No medicine available

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)