Ivermectin + Albendazole
Ascariasis, Trichuriasis, Strongyloidiasis, Enterbiasis. Onchocerciasis, Elephantiasis.
How it works
Ivermectin selectively binds and with high affinity to glutamate-gated and GABA (GABA)-gated chloride ion channels. This increases the permeability of the cell membrane to chloride ions leading to hyperpolarisation of muscles and nerve cells, thus ultimately causing paralysis and death of the parasites. Albendazole causes degenerative alterations in the intestinal cells of the worm by inhibiting polymerisation or assembly of tubules into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer and subsequent release of lysosomes result in decreased production of ATP (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilised and eventually dies.
Common side effects
Postural hypotension (low blood pressure), Rash, Joint pain, Diarrhoea, Dizziness, Fever, Itching, Muscle pain, Nausea, Urticaria, Vomiting, Weakness