1mg, best e pharmacy in India

insulin Glulisine



Diabetes mellitus.

How it works

Insulin glulisine binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC),

Common side effects

Application site itching, Bone-marrow suppression, Constipation, Injection site redness, Injection site swelling, Weight gain


Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)