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Imipenem

INFORMATION

Uses

Imipenem is used in serious bacterial infections.

How it works

Imipenem is an antibiotic. It kills the bacteria by attacking their cell wall. Specifically, it prevents the synthesis of a substance in the cell wall called peptidoglycan, which provides the cell wall with the strength required for survival of bacteria in human body.

Common side effects

Decreased urination, Bruise, Bleeding, Chills, Confusion, Convulsion, Diarrhoea, Abdominal pain, Dizziness, Shortness of breath, Fever, Rash, Itching, Sore mouth, Sore throat, Stomach upset, Facial swelling, Wheezing, Vomiting

AVAILABLE MEDICINE

Expert advice

  • Imipenem is given as a powder for solution for intravenous infusion by a doctor or nurse using a suitable infusion fluid.
  • Do not start or continue the imipenem, if you have kidney, liver, or urinary problems; history of fits (seizures) or central nervous system problems (e.g. tremors).
  • Do not take imipenem if you experience inflammation of the large intestine (colitis) or any other gastrointestinal disease.
  • Do not drive or operate heavy machinery because you may feel sleepy or dizzy while being treated with imipenem.
  • Avoid using imipenem, if you are pregnant, planning to become pregnant or breastfeeding.

Frequently asked questions

Imipenem

Q.Is imipenem a penicillin or beta lactam drug?
Imipenem is not a penicillin drug. It is a carbapenem beta-lactam antibiotic

Q.Is imipenem nephrotoxic or cause seizures?
Ganciclovir along with imipenem can increase risk of seizures. Imipenem generally not been shown to cause nephrotoxicity. Please consult your doctor if you experience these side effects

Q.What is imipenem-cilastatin used for?
Imipenem and cilastatin are used as combination therapy for bacterial infections. Cilastatin reduces the inactivation of imipenem from enzymes released from kidney and extends their spectrum of activity

Q.What organisms does imipenem cover?
Imipenem is active against most of the gram-positive and gram-negative bacteria, aerobes as well as anaerobes. It is effective against pseudomonas, legionella, and acinetobacter, and many other; not treatable by other antibiotics.


Content on this page was last updated on 24 November, 2016, by Dr. Varun Gupta (MD Pharmacology)