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Gramicidin also called Gramicidin D is a combinationation of three pairs of antibiotics viz., Gramicidin A, Gramicidin B and Gramicidin Cand is used to treat inflammation and bacterial infection in the eye and outer ear (otitis externa).

How it works

Gramicidin belongs to the class of medicines called peptide antibiotics. It acts on cell membrane (outer coating of bacteria) and causes disruption thus killing the bacteria responsible for causing infection.

Common side effects

Anal irritation, Cataract, Shortness of breath, Eye swelling, Lip swelling, Skin inflammation


No medicine available

Expert advice

  • Inform your doctor if symptoms do not disappear after 7 days of use. 
  • Do not drive or operate heavy machinery, or perform tasks which require concentration since gramicidin may cause blurred vision.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding. 
  • Do not take if allergic to gramicidin or any of the ingredients.
  • Do not take  in damaged ear drum, glaucoma (increased pressure inside the eye that causes visual problems), herpes keratitis (viral infection of the eye caused by herpes simplex virus); viral, fungal, tuberculous or pus-filled conditions of the eye.

Frequently asked questions


Q. Is gramicidin a penicillin, sulfa, or aminoglycoside antibiotic?
Gramicidin does not contain sulfa and is not a penicillin or aminoglycoside drug. It is a peptide antibiotic.
Q. How does gramicidin affect oxidative phosphorylation?
Gramicidin has no direct effect on oxidative phosphorylation.
Q. How does gramicidin work?
Gramicidin is a bactericidal for a variety of Gram-positive Bacteria. It increases the permeability of the bacterial cell membrane.

Q. If gramicidin is added?
Yes, gramicidin is generally available as combination with other medications.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)