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    Gliclazide + Metformin

    Information about Gliclazide + Metformin

    Gliclazide + metformin uses

    Gliclazide+Metformin is used in the treatment of type 2 diabetes.

    How gliclazide + metformin works

    This is a combination of two antidiabetic medicines: Gliclazide and Metformin. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

    Common side effects of gliclazide + metformin

    Hypoglycemia (low blood sugar level), Taste change, Nausea, Diarrhea, Stomach pain, Headache, Upper respiratory tract infection
    Content Details
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    Written By
    Dr. Betina Chandolia
    Writing in Sciences, PGCCL
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    Reviewed By
    Dr. Varun Gupta
    MD (Pharma), MBBS
    Last updated on:
    30 Nov 2018 | 06:20 PM (IST)
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    Expert advice for Gliclazide + Metformin

    • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
    • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Gliclazide + Metformin.
    • Take it with food to lower your chance of having an upset stomach.
    • Monitor your blood sugar level regularly while you are taking this medicine. 
    • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
    • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
    • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Gliclazide + Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
    • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

    Frequently asked questions for Gliclazide + Metformin

    Gliclazide + Metformin

    Q. What is Gliclazide+Metformin?

    Gliclazide+Metformin is a combination of two medicines: Gliclazide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Gliclazide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.

    Q. What are the possible side effects of Gliclazide+Metformin?

    The use of Gliclazide+Metformin is associated with common side effects. These side effects may include hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

    Q. Can the use of Gliclazide+Metformin cause hypoglycemia?

    Yes, the use of Gliclazide+Metformin can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.

    Q. Can the use of Gliclazide+Metformin cause lactic acidosis?

    Yes, the use of Gliclazide+Metformin can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin. It is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Gliclazide+Metformin and immediately consult your doctor.

    Q. Can the use of Gliclazide+Metformin lead to Vitamin B12 deficiency?

    Yes, the use of Gliclazide+Metformin can cause vitamin B12 deficiency on long-term use. The deficiency occurs as the medicine interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

    Q. Are there any specific conditions in which Gliclazide+Metformin should not to be taken?

    The use of Gliclazide+Metformin should be avoided in patients with known allergy to any of the component or excipients of this medicine. It is also avoided in patients with moderate to severe kidney disease or with underlying metabolic acidosis including diabetic ketoacidosis.

    Q. Is it safe to take alcohol while I am also taking Gliclazide+Metformin?

    No, it is not safe to take alcohol along with Gliclazide+Metformin. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.

    Content on this page was last updated on 30 November, 2018, by Dr. Varun Gupta (MD Pharmacology)