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Fosfomycin is used for treatment of urinary tract infections and cystitis (infection of urinary bladder).

How it works

Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.

Common side effects

Back pain, Diarrhoea, Dizziness, Pain during periods, Headache, Indigestion, Loss of appetite, Nausea, Running nose, Sore throat, Stomach upset, Vaginal itching, Vomiting, Fatigue


Expert advice

  • Only one dose of fosfomycin is needed to treat your UTI. Once taken, the medicine will continue to fight the infection.
  • The medicine is in powder form that must be mixed with water before using. Do not mix it with hot water and never swallow the medicine in its dry form.
  • If you are prescribed with tetracycline, take it at least 2 hours before or after you take fosfomycin.
  • Discuss with your doctor if you have diarrhea or any kidney disease.
  • Do not drive or operate machinery as fosfomycin may make you dizzy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. Is Fosfomycin a macrolide/sulfa drug/penicillin?
Fosfomycin is not macrolide/sulfa drug/penicillin. It is phosphonic acid derivative antibiotic.
Q. Can you take Fosfomycin with penicillin allergy/ does fosfomycin contain penicillin?
Fosfomycon does not contain penicillin and it can be taken with penicillin allergy.
Q. Does fosfomycin cover pseudomonas/ klebsiella/ proteus/ group b strep?
Fosfomycin works against pseudomonas, klebsiella and proteus but not against group b strep.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)