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Flutamide is used either alone or in combination to treat prostate cancer. Flutamide is also used to treat prostate cancer which has spread to other parts of the body (advanced cancer).

How it works

Flutamide belongs to a group of medicines called non-steroidal antiandrogens. Flutamide blocks the testosterone from reaching the cells by inhibiting the uptake of testosterone or by blocking the binding of testosterone to its receptors, thereby preventing the growth of these cancerous cells.

Common side effects

Nausea, Anorectal inflammation, Blood in urine, Cystitis, Diarrhoea, Development of breasts in men, Hot flashes, Impotence, Loss of libido, Rectal haemorrhage (bleeding), Vomiting


Expert advice

  • Do not drive or operate machinery as flutamide can affect your nervous system and cause visual changes.
  • Consult your doctor if you have any of the following medical conditions: liver disease, a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency, hemoglobin M disease; habit of smoking.
  • Seek immediate medical attention if you have severe or ongoing diarrhea.
  • Avoid dairy products such as milk, cheese, and yogurt to prevent diarrhea and do not use laxatives while taking flutamide.
  • Drink plenty of liquids while you are on flutamide treatment.

Frequently asked questions


Q. Is flutamide chemotherapy?
Flutamide is used as chemotherapy for the treatment of cancers.
Q. Is flutamide cytotoxic?
Yes, flutamide is cytotoxic (toxic to cells).
Q. Does flutamide cause weight gain?
Flutamide has no known effects on weight gain.
Q. Does flutamide lower testosterone?
Yes, flutamide lowers testosterone levels and blocks testosterone from reaching the cancer cells, thereby slowing the growth and of cancer cells.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)