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Flupirtine is used in pain.

How it works

Flupirtine belongs to a class of medicines called analgesics (painkiller). Flupirtine acts on various processes in the body that transmit pain perceptions (potassium (K+) channels). Flupirtine acts as a ‘selective neuronal-potassium-channel opener’; it opens specific pores on the surface of nerve cells called potassium channels due to which there is a  reduction in the excessive electrical activity (conduction) in the brain which contributes to painful states.

Common side effects

Liver enzyme increased, Drowsiness, Decreased blood pressure, Dizziness, Fatigue, Heartburn, Increased blood urea nitrogen, Increased creatine level in blood, Mood changes, Weakness, Dry mouth, Nausea


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Expert advice

If you are taking flupirtine, your treatment should not last longer than 2 weeks. Always follow the instructions of your doctor regarding its duration and use.Consult your doctor before you start flupirtine:
  • If you have liver problems or alcohol abuse problems.
  • If you are pregnant, breastfeeding or planning to get pregnant.
Stop taking flupirtine and consult a doctor, if you experience any signs of liver problems.If flupirtine is indicated in breastfeeding women, breastfeeding should be stopped, as safety has not been established in pregnant and breast feeding women.

Frequently asked questions


Q.What is flupirtine maleate?
Flupirtine belongs to a class of medicines called analgesics (painkiller). It is used in the management of acute (short term) pain and as a muscle relaxant.

Content on this page was last updated on 18 October, 2016, by Dr. Varun Gupta (MD Pharmacology)