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Ethionamide

INFORMATION

Uses

Ethionamide is used in tuberculosis (TB).

How it works

Ethionamide gets converted to its active form which acts as an antibacterial agent against Mycobacterium tuberculosis. It appears to inhibit a naturally occurring process called peptide synthesis and thus stops cell growth of Mycobacterium tuberculi, which results in cell death.

Common side effects

Nausea, Postural hypotension (low blood pressure), Liver transaminases increased, Depression, Diarrhoea, Dizziness, Bitter taste, Fall in blood sugar level, Gastrointestinal discomfort, Headache, Hepatitis (viral infection of liver), Reduced blood platelets, Tingling sensation of extremity, Numbness of extremity, Visual impairment, Vomiting

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Expert advice

  • You should always take ethionamide in combination with other anti-tubercular drugs as its use alone in the treatment results in the rapid development of drug-resistant tuberculosis. 
  • Always adhere to the drug regimen for the full duration of treatment as non-adherence to prescribed treatment can result in treatment failure and in the development of drug-resistant tuberculosis, which can be life-threatening and lead to other serious health risks. 
  • Tell your doctor if you have diabetes, liver problems, or vision problems.
  • You may be monitored with blood sugar, liver function, vision and thyroid function tests while on treatment with ethionamide.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • Ethionamide is not recommended in children below 12 years unless the organisms are found to be definitely resistant to primary therapy.

Frequently asked questions

Ethionamide

Q.What is ethionamide used for?
Ethionamide is used in combination with other medicines for the treatment of active tuberculosis (infectious disease caused by Mycobacterium tuberculosis).


Content on this page was last updated on 16 November, 2016, by Dr. Varun Gupta (MD Pharmacology)