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Doripenem

INFORMATION

Uses

Doripenem is used in serious bacterial infections.

How it works

Doripenem is an antibiotic. It kills the bacteria by attacking their cell wall. Specifically, it prevents the synthesis of a substance in the cell wall called peptidoglycan, which provides the cell wall with the strength required for survival of bacteria in human body.

Common side effects

Nausea, Blisters on skin, Convulsion, Diarrhoea, Fever, Difficulty in swalloing, Shortness of breath, Headache, Injection site swelling, Injection site pain, Injection site redness, Black and bloody stools, Skin rash, Itching, Sloughing

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Expert advice

  • Inform your doctor if you have a history of seizures (fits) or are on medications for fits (like valproic acid). In case you experience seizures while on treatment consult your doctor immediately.
  • Seek immediate medical attention if you develop severe skin rash, or diarrhea.
  • Evaluate if diarrhea occurs while on treatment as it can be life threatening resulting from Pseudomembranous colitis caused by Clostridium difficile.
  • Take doripenem medication for the full prescribed length even if you feel fine in order to help the infection get completely cleared.
  • Do not skip doses as this may increase your risk of further infections.
  • Do not take doripenem to treat a viral infection such as the common cold or flu.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions

Doripenem

Q.What is doripenem used for?
Doripenem is used to treat complicated urinary tract infections including pyelonephritis (inflammation of kidney due to bacterial infections), and complicated bacterial infections of the abdomen. Doripenem is also used to treat some nosocomial infections (infections acquired in the hospital facility) such as nosocomial pneumonia

Q.Does doripenem cover pseudomonas/ MRSA?
Yes, doripenem is active against pseudomonas, but not against MRS

Q.How does doripenem work?
Doripenem belongs to class of medications called carbapenem antimicrobials. It works by arresting the bacterial cell wall synthesis resulting in bacterial cell death.


Content on this page was last updated on 24 November, 2016, by Dr. Varun Gupta (MD Pharmacology)