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Divalproex is used in the treatment of epilepsy, mania (abnormally elevated mood) and migraine

How it works

Divalproex controls seizures or fits by suppressing the abnormal and excessive activity of the nerve cells in the brain.

Common side effects

Nausea, Nervousness, Rapid and repetitive movement of the eyes, Rash, Abdominal pain, Memory loss, Back pain, Bruise, Constipation, Depression, Diarrhoea, Double vision, Dizziness, Shortness of breath, Fever, Hair loss, Headache, Increased appetite, Indigestion, Infection, Influenza like syndrome, Loss of appetite, Respiratory tract inflammation, Ringing in ear, Sleepiness, Sore throat, Stomach inflammation, Swelling, Insomnia, Tremor, Unsteadiness, Visual impairment, Vomiting, Weakness, Weight gain

Available Medicine

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Expert advice

  • Do not take divalproex tablets if you are allergic (hypersensitive) to divalproex or any of the other ingredients of divalproex tablet.
  • Avoid taking divalproex if you are pregnant or breast feeding.
  • Do not take divalproex if you have family history of urea cycle disorder or unexplained infant deaths; history of mental or mood problems (e.g. depression) or suicidal thoughts or actions; if you have recurring vomiting and sluggishness, recurring extreme irritability, or decreased food or fluid intake.
  • Do not drive or operate machinery after taking divalproex because you may feel drowsy.
  • Doctor’s advice should be considered in case of patients with following history of disease conditions: cancer, alcohol abuse or dependence, liver problems, metabolic disease, blood disease (e.g. low levels of white blood cells, low blood platelet levels), HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems, mental retardation, inflammation of the pancreas, kidney problems, or high blood glycine levels.

Frequently asked questions


Q. Is divalproex an antipsychotic?
Divalproex is an anticonvulsant drug and not antipsychotic

Q. Is divalproex the same as Depakote?
Yes, Depakote is a trade name of product containing the drug divalproex sodium

Q. Is divalproex safe?
Divalproex is safe if used at prescribed dose and duration as advised by doctor

Q. Is divalproex a controlled substance?
No, it is not a controlled substance

Q. Is divalproex/ divalproex sodium a narcotic?
No, it is not a narcotic

Q. Is divalproex the same as valproic acid?
No, divalproex contains a compound of sodium valproate and valproic acid

Q. Is divalproex a benzodiazepine?
No, it is not a benzodiazepine

Q. Is divalproex addictive?
No, it is not addictive if used at prescribed dose and duration as advised by your doctor

Q. Can I take ibuprofen with divalproex?
Yes, but taking other medicines may alter the effects of divalproex. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required

Q. Does divalproex contain MAOI?
No, it does not contain MAOI

Q. Does divalproex make you sleepy/cause weight gain/hair loss?
Divalproex may cause these side effects. However, always consult your doctor if you experience any of these side effects.

Content on this page was last updated on 28 December, 2016, by Dr. Varun Gupta (MD Pharmacology)