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Diphenoxylate is used in combination with atropine (along with appropriate fluid and electrolyte therapy) for treatment of diarrhea, (loose stools).

How it works

Diphenoxylate belongs to a class of medications called antidiarrheal agents. It works by decreasing the movement of bowel.

Common side effects

Vomiting, Nausea, Numbness of extremity, Decreased urination, Abdominal bloating, Abdominal pain, Acne-like rash, Facial swelling, Allergic reaction, Confusion, Difficulty in swalloing, Shortness of breath, Flushing, Dry skin, Fatigue, Headache, Hoarseness of voice, Loss of appetite, Mood changes, Restlessness, Tachycardia, Itching, Urticaria


No medicine available

Expert advice

  • Appropriate fluid and electrolyte therapy should be given to protect against dehydration. If severe dehydration or electrolyte imbalance is present medication should be discontinued.
  • Consult your doctor before taking diphenoxylate, if you have heart, liver or kidney problems; Down syndrome (an inherited condition causing a range of developmental and physical problems);prostate problems (enlarged prostate); blockage of the bladder, trouble urinating, hiatal hernia, asthma, open-angle glaucoma, or risk factors for glaucoma.
  • Avoid exposure to hot weather or become over heated while you are being active; heatstroke may occur.

Frequently asked questions


Q. What is diphenoxylate hydrochloride and atropine sulfate?
Diphenoxylate and atropine combination medication is a combination medicine used for treatment of diarrhea.

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)