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Diphenoxylate is used for diarrhoea

How it works

Diphenoxylate decreases the perception of pain by blocking the transmission of pain signals to the brain.

Common side effects

Sweating, Headache, Dizziness, Decreased urination, Hoarseness of voice, Facial swelling, Shortness of breath, Sleepiness, Vomiting, Numbness of extremity, Weakness, Dehydration, Allergic reaction, Lightheadedness, Nausea, Edema, Abdominal pain, Dry mouth, Loss of appetite, Fatigue, Anemia, Itching, Acne-like rash, Dry skin, Tachycardia, Difficulty in swalloing, Abdominal bloating, Sedation, Confusion, Flushing (sense of warmth in the face, ears, neck and trunk), Urticaria, Mood changes, Constipation, Restlessness

Available Medicine

No medicine available

Expert advice

  • Appropriate fluid and electrolyte therapy should be given to protect against dehydration. If severe dehydration or electrolyte imbalance is present medication should be discontinued.
  • Consult your doctor before taking diphenoxylate, if you have heart, liver or kidney problems; Down syndrome (an inherited condition causing a range of developmental and physical problems);prostate problems (enlarged prostate); blockage of the bladder, trouble urinating, hiatal hernia, asthma, open-angle glaucoma, or risk factors for glaucoma.
  • Avoid exposure to hot weather or become over heated while you are being active; heatstroke may occur.

Frequently asked questions



What is diphenoxylate hydrochloride and atropine sulfate?
Diphenoxylate and atropine combination medication is a combination medicine used for treatment of diarrhea.

Content on this page was last updated on 02 February, 2017, by Dr. Varun Gupta (MD Pharmacology)