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Clindamycin + Nicotinamide

Written By Dr. Anuj SainiReviewed By Dr. Rajeev Sharma
Last updated 09 Feb 2026 | 01:25 PM (UTC)

Clindamycin + Nicotinamide Uses

Clindamycin+Nicotinamide is used in the treatment of acne.

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How Clindamycin + Nicotinamide works

Clindamycin + Nicotinamide is a combination of two medicines: Clindamycin and Nicotinamide, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. Nicotinamide is a form of vitamin B. It exerts anti-inflammatory effects when applied to the skin and reduces swelling, redness and tenderness associated with acne.

Common side effects of Clindamycin + Nicotinamide

Dry skin, Erythema (skin redness), Itching, Burning sensation, Worsening of acne
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Expert advice for Clindamycin + Nicotinamide

  • Clindamycin + Nicotinamide may take several weeks to show its action. Keep using it as suggested by your doctor.
  • Wash your skin with a mild cleanser and pat it dry before applying Clindamycin + Nicotinamide.
  • Apply it as a thin layer onto clean, dry, unbroken skin affected by acne.
  • It may cause minor burning, stinging or irritation when applied. Inform your doctor if this does not go away.
  • Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
  • It makes your skin more sensitive toward sunlight. Wear protective clothing or use sunscreen while stepping out.

Frequently asked questions for Clindamycin + Nicotinamide

No, do not overuse Clindamycin+Nicotinamide. It can cause over-absorption of the medicine into the body and cause severe diarrhea. If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation.
It is not a spot treatment and should not be used to treat a single pimple. Clindamycin+Nicotinamide should be applied to the entire face. Using it once everyday can help treat your acne.
It may take up to 2-3 weeks before your symptoms improve. Clindamycin+Nicotinamide may take some time to deliver significant results. Use the medicine as directed and let your doctor know if your symptoms do not improve or get worse.