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Ceftriaxone is used to treat bacterial infections of the brain respiratory tract ear abdomen abdominal wall, urinary tract and kidney, bones, joints, and skin or soft tissues. It is also used in the management of fever with low white blood cells (neutropenia), surgical site infections, joint pain caused by parasite ticks (Lyme disease), typhoid, paratyphoid and sexually transmitted infections (gonorrhea, syphilis).

How it works

Ceftriaxone belongs to group of medicines called cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptured, thereby killing the bacteria.

Common side effects

Vomiting, Nausea, Allergy, Flushing, Application site burning, Application site pain, Application site warmth, Chest pain, Dizziness, Diarrhoea, Skin rash, Fever, Headache, Heartburn, Black and bloody stools, Stomach cramp, Stomach pain, Bloating


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Expert advice

  • It is given as a drip (intravenous infusion) or as an injection directly into a vein or into a muscle. It is made up by the doctor, or nurse using water for injections or a suitable infusion fluid.
  • Do not drive because you may feel sleepy or dizzy while being treated with ceftriaxone.
  • Tell your doctor if you are taking, have recently taken or might take any other medicines. This includes medicines you can obtain without a prescription. 
  • Do not start or continue the ceftriaxone and consult your doctor if you have a liver or   kidney disease.
  • Do not take this drug and consult your doctor  if you are pregnant or planning to become pregnant or breastfeeding.

Frequently asked questions


Q. Is ceftriaxone a form of penicillin drug?
No, ceftriaxone is not a penicillin drug.

Q. Is it bactericidal or bacteristatic?
 It is a cephalosporin antibiotic. It is bactericidal drug.
Q. Is ceftriaxone safe in liver disease?
Yes, ceftriaxone is safe in liver disease. Please consult your doctor for your medical condition before taking the drug.
Q. Is ceftriaxone compatible with potassium or potassium chloride?
Yes, ceftriaxone is compatible with potassium or potassium chloride when taken together.
Q.Is ceftriaxone the same as cephalexin, Monocef-o, Monocef 200, Monocef tablet, Cefakind, or Cefakind 250?
No, all are different cephalosporin antibiotics. Monocef-o, Monocef 200, or Monocef tablet contain cefpodoxmine, and Cefakind, or Cefakind 250 contain cefuroxime.
Q. What organisms does ceftriaxone cover?
Ceftriaxone is active against pseudomonas, staphylococcus, and klebsiella bacteria. It has no activity against chlamydia, methicillin-resistant Staphylococcus aureus (mrsa), and mycoplasma.

Content on this page was last updated on 15 October, 2016, by Dr. Varun Gupta (MD Pharmacology)