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Cefoperazone is used to treat bacterial infection of the respiratory tract, the abdomen and abdominal wall (peritonitis), the urinary tract, the female genital tract (endometritis, pelvic inflammatory disease), the blood (septicemia), and the skin and soft tissues. 

How it works

Cefoperazone belongs to group of medicines called third-generation cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria. 

Common side effects

Nausea, Increased creatine level in blood, Increased urea nitrogen level in blood, Liver enzyme increased, Allergic reaction, Decreased haemoglobin level in blood, Diarrhoea, Inflammation of vein, Drug fever, Decreased white blood cell count, Decreased white blood cell count (eosinophils), Vomiting


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Expert advice

Cefoperazone is usually given by a doctor or a nurse as an injection directly into the vein or muscle. Tell your doctor if you are taking cefoperazone and undergoing any blood or urine test, as it may affect the result. Do not start or continue the cefoperazone and consult your doctor:
  • If you have history of allergy due to cefoperazone or any other cephalosporin or penicillin antibiotics.
  • If you experience severe and persistent diarrhea after taking antibiotics.
  • If you are already taking any other antibiotic like aminoglycosides or other cephalosporins as it may cause kidney toxicity.

Frequently asked questions


Q. What is cefoperazone sulbactam?
Combination of cefoperazone and sulbactam (beta lactamase inhibitor) are used for the treatment of intra-abdominal infections.
Q. Is cefoperazone nephrotoxic?
No, cefoperazona is not a nephrotoxic drug when given alone, but when given along with aminoglycosides (gentamicin, tobramycin) or other cephalosporins antibiotics, it may increase nephrotoxicity. Please consult your doctor before taking the drug.
Q. Is cefoperazone safe?
Cefoperazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Content on this page was last updated on 03 October, 2016, by Dr. Varun Gupta (MD Pharmacology)