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Cefepime is used to treat respiratory tract infection like lung infection (pneumonia), urinary tract infections such as kidney infection (pyelonephritis), skin and soft tissue infections, intra-abdominal Infections, and fever associated with low white blood cells called neutrophils (febrile neutropenia).

How it works

Cefepime belongs to group of medicines called cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptured, thereby killing the bacteria.

Common side effects

Vomiting, Nausea, Itchy rash, Acne-like rash, Bloody diarrhea, Confusion, Convulsion, Shortness of breath, Sore mouth, Sore throat, Stomach pain, Watery diarrhoea, Chills, Fever


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Expert advice

  • Do not start or continue the cefepime and consult your doctor if you have kidney, liver or blood clotting disorder, stomach or bowel problems, poor nutrition, or if you are taking drugs like aminoglycosides (e.g. gentamycin) and diuretics (e.g. furosemide).
  • Caution should be taken when given to the children < 2 months old or to patients with diabetes as it may affect the results for urine glucose tests.

Frequently asked questions


Q. Is cefepime beta lactam, penicillin, or sulfa drug?
Cefepime does not contain sulfa and is not a penicillin drug. It is a beta lactam cephalosporin antibiotic.
Q. Is cefepime broad spectrum bacteriostatic or bactericidal?
Cefepime is a broad spectrum bactericidal antibiotic.
Q. Is cefepime compatible with lactated ringer's, normal saline, or vancomycin?
Cefepime is compatible with lactated ringer’s or normal saline. Solutions of cefepime should not be added to vancomycin. However, if concurrent therapy with cefepime is indicated, vancomycin can be administered separately. Please consult your doctor before taking the drug.
Q. Is cefepime a vesicant?
No, cefepime is not a vesicant drug.
Q. What organisms does cefepime cover?
Cefepime is mainly effective against methicillin-sensitive Staphylococcus aureus (mssa), gram-negative bacteria, klebsiella, Group B streptococci but not effective against enterococcus, methicillin-resistant Staphylococcus aureus (mrsa), or anaerobes such as mycoplasma.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)