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Adapalene + Clindamycin

Written By Dr. Sakshi JainReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:37 AM (UTC)

Adapalene + Clindamycin Uses

Adapalene+Clindamycin is used in the treatment of acne.

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How Adapalene + Clindamycin works

Adapalene + Clindamycin is a combination of two medicines: Adapalene and Clindamycin, which treats pimples (acne). Adapalene is a form of vitamin A which prevents accumulation of the sebum (skin’s natural oil), unblocks the pores and allows natural exfoliation of the outer layers of skin. Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria.

Common side effects of Adapalene + Clindamycin

Dry skin, Erythema (skin redness), Skin irritation, Burning sensation
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Expert advice for Adapalene + Clindamycin

  • Apply it as a thin layer onto clean, dry, unbroken skin affected by acne.
  • Avoid getting it in your eyes or mouth. If this happens, rinse with water immediately.
  • Do not apply to broken, sunburnt or sensitive areas of skin. Inform your doctor if you notice unusual dryness, redness, and peeling of the skin.
  • It makes your skin more sensitive toward sunlight. Apply sunscreen or wear protective clothing while stepping out.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Frequently asked questions for Adapalene + Clindamycin

It is not a spot treatment and should not be used to treat a single pimple. Adapalene+Clindamycin should be applied to the entire face. Using it everyday can treat your acne.
It may take up to 2-3 weeks before your symptoms improve. Adapalene+Clindamycin may take some time to deliver significant results. Use the medicine as directed and let your doctor know if your symptoms do not improve or get worse.
No, do not overuse Adapalene+Clindamycin. It can cause over-absorption of the medicine into the body and cause severe diarrhea. If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation.