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MRP: Rs. 42.30 for 1 strip(s) (10 tablets each)
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food interaction for MIGRANIL

alcohol interaction for MIGRANIL

pregnancy interaction for MIGRANIL

lactation interaction for MIGRANIL

There is no data available. Please consult doctor before consuming the drug.
Migranil tablet may cause excessive drowsiness and calmness with alcohol.
Taking caffeine with alcohol may impair the motor coordination
Migranil tablet is highly unsafe in women who are or may become pregnant.
Human and animal studies have shown significant adverse effects on the fetus and should not be given under any circumstances. Please consult your doctor.
Migranil tablet is probably unsafe to use during breastfeeding. Please consult your doctor.


Caffeine(100 mg)


Caffeine is used in combination with pain killers (aspirin and paracetamol) to ease pain that includes headache, migraine, neuralgia, toothache, sore throat, period pains, relief of sprains, strains, rheumatic pain, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds. As caffeine citrate, it is used to treat absence of breathing seen in newborns (primary apnea of premature newborns).

How it works

Caffeine is a drug which belongs to a group of medicines called methylxanthines. Caffeine acts against a chemical called adenosine in the body, and thereby reduces pain. Caffeine also stimulates the brain (central nervous system), heart, and muscles and improves the drive to breathe.

Common side effects

Frequent urge to urinate, Abdominal pain, Anxiety, Excitement, Flushing, Altered heart rate, Insomnia, Restlessness, Tremor
Ergotamine(1 mg)


Ergotamine is used (usually in combination with caffeine and cyclizine) to relieve the symptoms of a migraine attack.

How it works

Ergotamine belongs to a class of drugs called as ergot derivatives. It acts by narrowing the blood vessels in and around the brain, thus increasing the blood pressure and reducing the headache associated with migraine.

Common side effects

Vomiting, Nausea, Allergic reaction, Itching, Facial swelling, Blue hands and feet, Tachycardia, Bradycardia, Chest pain, Dizziness, Muscle pain, Tingling sensation of extremity, Numbness of extremity, Weakness, Limb pain
Paracetamol(250 mg)


Paracetamol is used for the relief of mild to moderate pain in conditions such as headache (including migraine), toothache, ear pain, joint pain, pain during menstruation, fever, feverish colds, and flu.

How it works

Paracetamol belongs to class of medications called analgesics (painkiller) and antipyretics (fever reducing). Paracetamol reduces pain by increasing the pain threshold. It reduces fever by acting on the temperature-regulating region of brain, resulting in increased blood flow across the skin, sweating and heat loss.

Common side effects

Skin redness, Allergic reaction, Shortness of breath, Running nose, Nausea, Liver injury, Abnormal blood cell count, Facial swelling, Blisters on skin
belladonna dry extract(10 mg)


How it works

Common side effects


1 Substitutes
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Expert advice for MIGRANIL

  • For relief of pain, consume the medicine only at recommended doses. Immediately consult doctor in case you take more than the prescribed/ recommended dose even if you feel well. Also consult the doctor if the symptoms last for more than 3 days despite taking the medicine.
  • Preparations of caffeine and ergot derivatives have been discontinued in view of patient safety.
  • When caffeine citrate solution is used for premature apnea of newborns, remember to use one vial of the drug for one dose. Throw away the left-over solution after required amount is used.

Frequently asked questions for MIGRANIL


Q. What is caffeine? 
Caffeine is a drug which belongs to a group of medicines called methylxanthines. It is also present in tea, coffee, some chocolates and soft drinks, in addition to some medicines. It acts on the brain to increase alertness and energy levels. However, too much caffeine is harmful.
Q. Is caffeine alcohol? 
No, caffeine is not alcohol; it belongs to a group of medicines called methylxanthines. It acts on the brain to increase alertness and energy levels. However, it must be remembered that too much caffeine is harmful.
Q. Is caffeine good or bad?
Caffeine; if taken as medicine for recommended indications and in adequate dosage it provides beneficial effects. Too much caffeine is harmful. Always consult your doctor if you get any of the bad effects or side effects after use of caffeine.
Q. Is caffeine good for hair?
There is no report available on the use of caffeine and hair growth. Patients should follow the advice of the doctor regarding its use.
Q. Is caffeine addictive?
No, caffeine is not in the list of addictive drugs. Addiction is said to occur when there is persistent, compulsive dependence on a behavior or substance; without treatment or engagement in recovery activities, addiction is progressive and can result in disability or premature death. Caffeine does not meet this definition. However, people who have taken it for long may experience "caffeine withdrawal" symptoms like headache, anxiety, fatigue, drowsiness or depression, 12–24 hours after the last dose of caffeine but resolves within 24–48 hours. 
Q. Is caffeine good for heart?
Caffeine is a central nervous system stimulant, and is used in combination with pain-relieving medication to ease headache, migraine pain, neuralgia, toothache, sore throat and period pains. Increased doses may have side effects like increased heart rate (tachycardia), abnormal heart beats (cardiac arrhythmias). Always consult your doctor for the recommended indications, doses and side effects, if any.


Q. Is ergotamine available or sold over the counter?
No. it is a prescription drug. It is not available or sold over the counter.
Q. Is ergotamine a controlled substance/narcotic/addictive?
No it is not a controlled substance/addictive/narcotic. However, it is available only on prescription of a doctor.
Q. Is ergotamine safe?
Ergotamine has numerous side-effects, some of which can be serious.
Q. Do Topamax (topiramate)/Imitrex (sumatriptan succinate)/ Maxalt (rizatritan benzoate)/Tremimet (sumatriptan and naproxen)/Zomig (zolmitriptan)/ sumariptan/amitriptyline contains ergotamine?
No, these drugs do not contain ergotamine.
Q. Where does ergotamine come from?
Ergotamine is obtained from a fungus Claviceps purpurea and similar fungi.


Q. Is paracetamol safe/ banned/ available in India?
Paracetamol (also known as acetaminophen, crocin, dolo, calpol, pacimol) is an over-the-counter drug available in India. It is generally safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is paracetamol a painkiller/ used for cold?
Paracetamol is used to relieve mild to moderate pain associated with cold and flu, as well as fever.
Q. Does paracetamol make you drowsy / sleepy? 
Paracetamol does not cause drowsiness. However, paracetamol is available in combination with cough and cold medicines (eg. cetirizine, chlorpheniramine), which may cause drowsiness or sleepiness.
Q. Is paracetamol an NSAID/ antibiotic?
Paracetamol is a anti-pyretic (anti-fever), anti -inflammatory drug, which belongs to the category of non-steroidal anti-inflammatory drug (NSAID). However, unlike other NSAIDS, paracetamol can relieve only mild to moderate pain.
It is not an antibiotic.
Q. Can I take crocin with cetirizine/ aceclofenac/ amoxicillin/ codeine/ tramadol/ warfarin/ erythromycin/ antibiotics?
Yes, paracetamol (available as crocin) can be taken with all of these drugs. Caution is advised when crocin is to be used with warfarin. However, always consult your doctor regarding combined use of crocin with any other drug.
Q. Can I take crocin with ibuprofen/naproxen/other NSAID?
Paracetamol (available as crocin) is available over-the-counter in combination with ibuprofen/naproxen/other NSAID. However, always consult your doctor regarding combined use of crocin with any other drug.
Q. Does paracetamol cause death?
Paracetamol on overdose can severely damage the liver and cause death. No more than 4 grams should be consumed in one day. Always consult your doctor regarding use of paracetamol.
Q. Can calpol make babies/ toddlers sleep/ help in teething pain?
Calpol can relieve pain in infants and children; it does not make them sleep.


Content on this page was last updated on 31 August, 2016, by Dr. Varun Gupta (MD Pharmacology)