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Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Acetylcholine Receptor (ACHR) Binding Antibody

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Understanding Acetylcholine Receptor (ACHR) Binding Antibody

What is Acetylcholine Receptor (ACHR) Binding Antibody?

Acetylcholine receptor antibodies, also known as ACHR antibodies, are autoantibodies produced by the body's immune system. These antibodies incorrectly target proteins called acetylcholine receptors located in muscle fibers. This test also determines whether someone has blocked receptors, causing a breakdown in the link between the muscles and the nerves - leading to a disorder known as myasthenia gravis. A patient may experience drooping eyes, double vision, feeble muscles, and trouble breathing.

This blood test detects and measures the presence and level of these acetylcholine receptor antibodies in the blood. A timely blood test helps monitor the individual to check the response to treatment. The test measures how much ACHR is present in the body. The test shows up to 90% sensitivity to this disorder and confirms the diagnosis.

What is Acetylcholine Receptor (ACHR) Binding Antibody used for?

An acetylcholine receptor (AChR) antibody test helps to determine the condition of myasthenia gravis (MG) and helps to differentiate it from conditions that can cause the same kind of symptoms. These symptoms are weakness and muscle fatigue.

Interpreting Acetylcholine Receptor (ACHR) Binding Antibody results


AchR are basically autoantibodies which are generated as a result of autoimmune response. A person is most likely to suffer from myasthenia gravis if he or she has the symptoms of the condition and has the antibodies. However, a negative test result does not entirely rule out the possibility of myasthenia gravis.


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