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What is Transcobalamin?
Transcobalamin binds and transports vitamin B12 in the circulation. Transcobalamin deficiency is a disorder that impairs the transport of cobalamin (also known as vitamin B12) within the body. The first signs of transcobalamin deficiency are typical failure to gain weight and grow at the expected rate (failure to thrive), vomiting, diarrhea, and open sores.
This test is prescribed by the doctor in case a person you have signs or symptoms indicative of vitamin B12 deficiency anemia like pale skin, dizziness, oral ulcers, forgetfulness, confusion, and rapid heartbeat.
Why is Transcobalamin done?
- If you have symptoms of gastro intestinal disease like difficolty gaining weight, repeated diarrhea and/or vomiting, dizziness
- If you have signs or symtoms indicative of vitamin B12 deficinecy anemia like pale skin, dizziness, oral olcers, forgetfolness, confusion, rapid heart beat, poor appetite
- If you have symptoms like tingling numbness in hands/feet, muscle twitching
- If you have symptoms of liver disease or history of alcoholism
Interpreting Transcobalamin results
- High levels of transcobalamine are rare and occur due to excessive nutritional supplements or injections
- Low levels of transcobalamine usually indicate megaloblastic anemia due to vitamin B12 deficiency which can be due to poor intake in diet, poor absorption from gut like Celiac disease
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