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Written by
Dr. Betina Chandolia
BDS, MDS - Oral Pathology and Microbiology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Alpha 2 Macroglobulin

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What is Alpha 2 Macroglobulin?

Alpha 2 Macroglobulin is a lab test used to measure the amount of alpha 2 macroglobulin in blood. Alpha 2 macroglobulin is a plasma protein produced by the liver and has diverse functions in the body. The alpha 2 macroglobulin test is used to diagnose nephrotic syndrome and proteinuria. In people less than 18 years old, the normal range of serum plasma protein is between 178 and 495 mg/dL. In healthy adults, the plasma protein levels are around 100 to 280 mg/dL.

Increased levels of alpha 2 macroglobulin are observed in nephrotic syndrome. In this condition, the kidneys leak smaller proteins like albumin, while Alpha 2 macroglobulin is retained because of its larger size. Increased levels of alpha 2 macroglobulin are also observed in liver cirrhosis and diabetes.

Why is Alpha 2 Macroglobulin done?

The test is usually performed to identify Proteinuria and Nephrotic Syndrome. It is linked to patients with chronic liver diseases and diabetes. If the concentration is lower it is associated with patients with pancreatitis, rheumatoid arthritis and multiple myeloma.



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