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Topiroxostat
INFORMATION ABOUT TOPIROXOSTAT
Topiroxostat Uses
Topiroxostat is used in the treatment of gout.
How Topiroxostat works
Gout occurs due to increased blood uric acid levels. Topiroxostat reduces the synthesis of uric acid by inhibiting the enzyme involved in it.
Common side effects of Topiroxostat
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Increased liver enzymes
CONTENT DETAILS
Written By
Dr. Sakshi Jain
MS, BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
10 Apr 2025 | 04:40 AM (UTC)
We provide you with authentic, trustworthy and revelant information
Read our editorial policy
Medicine brands for Topiroxostat
Topimac
₹93 to ₹243
Macleods Pharmaceuticals Pvt Ltd
3 variant(s)
Tapiristat
₹93 to ₹93
Abbott Healthcare Private Limited
1 variant(s)
Toxur
₹103 to ₹185
Blisson Mediplus Pvt Ltd
3 variant(s)
Topiroxo
₹113 to ₹203
Alkem Laboratories Ltd
2 variant(s)
Expert advice for Topiroxostat
  • Take adequate water or fluids while taking Topiroxostat to prevent kidney stones.
  • Treatment with this medicine should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication.
  • Consult your doctor before taking it if you have or ever had kidney stones, stomach ulcers, peptic ulcers, diabetes, liver disorders or blood disorders.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
  • Your doctor has prescribed Topiroxostat to reduce episodes of gout attack.
  • Take it at the same time every day, with or without food.
  • Take plenty of fluids (2-3 litres) daily while on Topiroxostat.
  • When you first start taking this medicine, you might have more gout attacks. Do not stop Topiroxostat on having an acute attack of gout as that could make an attack worse.
  • Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Notify your doctor if you develop a rash. This could be a sign of allergy and should go away on discontinuing Topiroxostat.
Frequently asked questions for Topiroxostat
The usual adult dosage of Topiroxostat is 20 mg/dose orally given twice daily in the morning and evening. Thereafter, the dosage should be gradually increased, as needed, while monitoring blood uric acid levels. The usual maintenance dosage should be 60 mg/dose twice daily. The dose may be adjusted based on the patient’s condition, up to 80 mg/dose twice daily.
Patients with kidney disease should be given Topiroxostat with caution due to the higher risk of side effects in these patients.
The dose of Topiroxostat should be increased gradually, i.e., starting dose should be 20 mg/dose twice daily, and the dose should be increased gradually, for example, to 40 mg/dose twice daily at or after Week 2, and then to 60 mg/dose twice daily at or after Week 6. The patient should be adequately monitored after the dose increase.