Lemborexant
Written By Dr. Lipika Khurana
Reviewed By Dr. Rajeev SharmaLast updated 25 Nov 2025 | 09:34 AM (UTC)
Lemborexant Uses
Lemborexant is used in the treatment of insomnia.
How Lemborexant works
Lemborexant blocks the action of orexin, a chemical that regulates the sleep signals in the brain and keeps you awake. Once orexin’s action is blocked, the brain doesn’t receive wake-up signals, which helps you sleep.
Common side effects of Lemborexant
Drowsiness, Headache, Tiredness, Nightmares, Suicidal behaviors
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Expert advice for Lemborexant
- Lemborexant can make you feel drowsy, therefore, patients, especially the elderly, may be at a higher risk of falls. Caution is advised.
- Take Lemborexant right before going to bed and only when you can stay in bed for a full night (at least 7 hours).
- Do not take Lemborexant with other medicines that can make you sleepy, unless your healthcare provider tells you to.
- Never share your medication with any other person who also has a sleep problem.
- Discuss it with your doctor if you develop unusual and strange thoughts or behavior while using Lemborexant.
- Stop taking the medication and inform your doctor if you experience complex sleep behaviors, including sleep-walking, sleep-driving, preparing and eating food, making phone calls, or having sex while not being fully awake.
- Make sure to regularly visit your doctor to check your progress and any side effects.
Frequently asked questions for Lemborexant
Studies suggest that Lemborexant may cause drowsiness, decreased mental alertness, prolonged reaction time, problems with coordination the day after you take it, blurry or double vision, and may increase the risk of falling. People taking Lemborexant should be instructed to avoid driving, using heavy machinery, or doing any activity that requires concentration to avoid any mishaps or accidents. Caution should be exercised particularly in elderly patients taking this drug, to avoid any falls.
People who fall asleep unexpectedly and at unusual times or who sleep more often during the day (narcolepsy) should avoid taking Lemborexant. Taking this medicine can worsen the sleeping habits of such individuals.
Lemborexant may interact with other prescription and nonprescription medications; therefore, you must inform your doctor about any other medicines you are taking before starting the treatment with Lemborexant. Your doctor may tell you not to take Lemborexant, may need to change the doses of your medications, or monitor you carefully for side effects.
It is best to take Lemborexant just before you go to bed. This will ensure that you get a sound sleep at night and benefit from this medicine.
It is unknown whether Lemborexant can be taken during pregnancy or not. Therefore, it is best to avoid using the medicine in pregnant women to avoid any potential harm to the baby.