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Diphenhydramine Topical



Diphenhydramine topical is used to temporarily relieve pain caused due to insect bites and/or itching associated with sunburn, minor –burns, cuts, scrapes, skin irritations and rashes caused by certain poisonous plants such as ivy, oak and sumac.

How it works

Diphenhydramine belongs to the group of medications called as antihistamines. It acts by blocking production of a certain natural substance (histamine) that is produced in the body thereby reducing symptoms of allergy.

Common side effects

Skin irritation


Expert advice

  • Diphenhydramine cream or ointment is for external use only. Avoid contact with the eyes, nose and mouth area. 
  • Do not use diphenhydramine cream for more than 3 days.
  • Avoid using the diphenhydramine cream on broken skin and/or larger areas of skin.
  • Inform your doctor if you are using another medicine containing diphenhydramine. 
  • Tell your doctor if you are pregnant, planning to become pregnant.
  • It should not take if patient is allergic to diphenhydramine or any of its ingredients.
  • It sholud not given to patients with skin disease like eczema. 
  • It sholud not given to children <2 years.
  • It sholud not given to breastfeeding women.

Frequently asked questions

Diphenhydramine Topical

Q. Is diphenhydramine topical a blood thinner/narcotic/water soluble?
No, it is an antihistaminic drug and not a blood thinner or narcotic.
Q. Is diphenhydramine hydrochloride safe?
It is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)