Transglutaminase, IgG
Understanding Transglutaminase, IgG
What is Transglutaminase, IgG?
The Transglutaminase, IgG test detects Immunoglobulin G (IgG) antibodies against tissue transglutaminase (tTG), an enzyme targeted by the immune system in individuals with celiac disease. This test is often part of broader food intolerance tests that assess IgG levels for various foods. This condition occurs when the body reacts to gluten, a protein found in wheat, barley, and rye. Doctors may recommend this test if you experience signs such as persistent abdominal pain, bloating, chronic diarrhea, weight loss, anemia, or an itchy, blister-like rash known as dermatitis herpetiformis. It is also helpful in monitoring the effectiveness of a gluten-free diet and screening individuals with a family history of celiac disease or other autoimmune disorders. By identifying the immune system’s delayed reaction to transglutaminase, this test helps healthcare providers assess gluten-related sensitivity and guide personalized dietary changes. Early identification and management can help reduce symptoms, support gut healing, and improve long-term digestive health.
What does Transglutaminase, IgG measure?
The Transglutaminase, IgG test detects Immunoglobulin G (IgG) antibodies directed against tissue transglutaminase (tTG), an enzyme found in the lining of the small intestine. In individuals with celiac disease, the immune system mistakenly identifies this enzyme as harmful and produces IgG antibodies against it when gluten is consumed. Elevated levels of IgG antibodies indicate an immune response to gluten consumption. It is important to understand that this test doesn't diagnose allergy. It's more related to food sensitivities or intolerances, which are different from allergies and can be caused by a variety of factors, including difficulty digesting or metabolizing certain food stuffs. In contrast, food allergies are usually immediate and IgE-mediated and tested by other tests which measure allergen specific IgE . Identifying such immune responses can help pinpoint food triggers, enabling doctors to recommend personalized dietary changes.
Other tests
