Test Detail
Understanding the Test
Test Measures
Interpreting Results
References
Other Tests
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Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old

Also known as Fever panel, Fever profile
Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old Includes 49 testsView All
This test is for
Male, Female

Understanding Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old


What is Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old?

The Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old consists of a series of tests that help detect common fever-causing illnesses. This package provides a thorough assessment of your health status, helping to identify the presence of viral or bacterial infections that may be causing fever. 

The Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old includes a set of blood and urine tests that allows for a comprehensive assessment of the individual's health status, helping doctors in accurate diagnosis and treatment planning. This package targets the identification of the underlying cause of fever and associated symptoms, especially caused by illnesses like dengue, malaria, typhoid, chikungunya, urinary tract infections, etc. Additionally, it includes tests such as complete blood count (CBC), peripheral blood smear, Erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) to detect abnormalities in blood cell counts and measure inflammation in the body, both commonly associated with fever. 

Understanding the causes of fever is challenging as it can stem from multiple factors like infections (such as cold or flu), reactions to medications or vaccines as well as conditions like inflammation or heat exhaustion. However, if a fever becomes too high or lasts for a prolonged period, it's important to manage it. Therefore, the Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old is customized to help understand and manage your fever effectively to reduce its impact and subsequent complications. 

The Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old is usually advised for individuals presenting with symptoms such as fever, chills, body aches, general weakness, irritability, and other symptoms suggestive of infectious or inflammatory conditions. This package may also be useful for individuals with a recent history of travel to areas endemic for dengue, malaria, or typhoid or those with known exposure to these diseases. 

Usually, overnight fasting is preferred for these tests. A urine sample should be collected into a sterile container provided by the sample collection professional. Women are advised not to give the sample during the menstrual period unless prescribed, as that can interfere with certain test results. You are required to submit all the samples that are a part of this package during the sample collection itself.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. Discuss your symptoms and medical history to help the doctor correlate your clinical and laboratory findings, leading to a more accurate diagnosis and effective treatment plan tailored to your specific health needs.

What is Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old used for?

The Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old is done:

  • To identify specific infectious agents causing the fever.
  • To determine the severity of an infection or inflammation causing the fever.
  • If you are suffering from low-grade or high-grade fever for an extended period. 
  • If you have signs or symptoms of typhoid (enteric) fever like headache, high fever, abdominal pain, diarrhea, weight loss, or skin rashes.
  • If you have signs or symptoms of mosquito and mite-borne infections such as dengue, malaria, or chikungunya. 
  • To assess whether the cause of fever involves urinary tract infections.
  • In cases of pyrexia of unknown origin (PUO).

What does Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old measure?

Contains 49 tests

The Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old is tailored that help detect the potential cause of your underlying fever and associated symptoms. It usually comprises a combination of blood and urine tests that help screen for illnesses such as dengue, malaria, chikungunya, typhoid, and urinary tract infections. It comprises 49 tests that include dengue fever NS1 antigen test, malarial antigen (vivax and falciparum) detection test, widal test, chikungunya IgM antibody test, typhidot IgG and IgM test,  complete blood count test along with peripheral smear and urine examination. Moreover, it includes a C-reactive protein (CRP) test and erythrocyte sedimentation rate (ESR) test which help identify the presence of inflammation in the body causing fever.

The aim of the Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old is to detect specific markers, pathogens, or antibodies associated with fever to provide a comprehensive assessment of your health to guide appropriate treatment based on the identified cause of the fever. 

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ESR (Erythrocyte Sedimentation Rate)

An ESR test measures the rate at which red blood cells (erythrocytes) settle (sediment) in one hour at the bottom of a tube that contains a blood sample.

When there is inflammation in the body, certain proteins, mainly fibrinogen, increase in the blood. This increased amount of fibrinogen causes the red blood cells to form a stack (rouleaux formation) that settles quickly due to its high density, leading to an increase in the ESR.

An ESR test is a non-specific measure of inflammation and can be affected by conditions other than inflammation. This test cannot identify the exact location of the inflammation in your body or what is causing it. Hence, an ESR test is usually performed along with a few other tests to identify or treat possible health concerns.

Know more about ESR (Erythrocyte Sedimentation Rate)

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Dengue Fever NS1 Antigen, EIA

The Dengue Fever NS1 Antigen, EIA test measures the NS-1 protein of the dengue virus. This protein is secreted into the blood during the infection; hence, it can only be detected during the early stages of the illness. It is recommended to do the Dengue Fever NS1 Antigen, EIA test in the first 5 days of fever. After 7-10 days of continuous fever, the recommended test is Dengue fever antibodies IgG & IgM.

Dengue fever may progress to dengue hemorrhagic fever or dengue shock syndrome if left untreated. Dengue hemorrhagic fever (DHF) includes variable manifestations like bleeding, vomiting blood, passing blood in the stool, difficulty breathing, and cold, clammy skin, especially in the extremities. If progressed, the virus may attack blood vessels, causing capillaries to leak fluid into the space around the lungs (pleural effusion) or the abdominal cavity (ascites).

Dengue shock syndrome (DSS) is a severe complication of dengue fever caused when the body's immune system overreacts to the dengue virus. It can lead to a sudden drop in blood pressure and dehydration; if not managed timely, it may lead to multiple organ failures. 

There is no specific treatment for dengue, but early diagnostic testing, such as the Dengue Fever NS1 Antigen, EIA test, can prevent the advancement of dengue to its complicated forms.

Know more about Dengue Fever NS1 Antigen, EIA

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CBC (Complete Blood Count)

The CBC (Complete Blood Count) test evaluates red blood cells (RBCs), white blood cells (WBCs}, and platelets. Each of these blood cells performs essential functions–RBCs carry oxygen from your lungs to the various body parts, WBCs help fight infections and other diseases, and platelets help your blood to clot–so determining their levels can provide significant health information. A CBC test also determines the hemoglobin level, a protein in RBC that carries oxygen from the lungs to the rest of your body. Evaluating all these components together can provide important information about your overall health.

Know more about CBC (Complete Blood Count)

  • Differential Leukocyte Count

  • There are five types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. A Differential Leukocyte Count test measures the percentage of each type of WBC in the blood. Leukocytes or WBCs are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

    This further contains

    • Differential Neutrophil Count
    • Differential Lymphocyte Count
    • Differential Monocyte Count
    • Differential Eosinophil Count
    • Differential Basophil Count
  • Red Blood Cell Count

  • The Red Blood Cell Count test measures the total number of red blood cells in your blood. RBCs are the most abundant cells in the blood with an average lifespan of 120 days. These cells are produced in the bone marrow and destroyed in the spleen or liver. Their primary function is to help carry oxygen from the lungs to different body parts. The normal range of RBC count can vary depending on age, gender, and the equipment and methods used for testing.

  • Hb (Hemoglobin)

  • An Hb (Hemoglobin) test measures the concentration of hemoglobin protein in your blood. Hemoglobin is made up of iron and globulin proteins. It is an essential part of RBCs and is critical for oxygen transfer from the lungs to all body tissues. Most blood cells, including RBCs, are produced regularly in your bone marrow. The Hb test is a fundamental part of a complete blood count (CBC) and is used to monitor blood health, diagnose various blood disorders, and assess your response to treatments if needed.

  • Platelet Count

  • The Platelet Count test measures the average number of platelets in the blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days. 

    Platelets help stop the bleeding, whenever there is an injury or trauma to a tissue or blood vessel, by adhering and accumulating at the injury site and releasing chemical compounds that stimulate the gathering of more platelets. A loose platelet plug is formed at the site of injury and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps, including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this step, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding. 

  • Total Leukocyte Count

  • The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

  • Hematocrit

  • The Hematocrit test measures the proportion of red blood cells (RBCs) in your blood as a percentage of the total blood volume. It is a crucial part of a complete blood count (CBC) and helps in assessing your blood health. RBCs are responsible for carrying oxygen from the lungs to different parts of the body. The hematocrit test provides valuable information about your blood's oxygen-carrying capacity.

    Higher-than-normal amounts of RBCs produced by the bone marrow can cause the hematocrit to increase, leading to increased blood density and slow blood flow. On the other hand, lower-than-normal hematocrit can be caused by low production of RBCs, reduced lifespan of RBCs in circulation, or excessive bleeding, leading to a reduced amount of oxygen being transported by RBCs. Monitoring your hematocrit levels is essential for diagnosing and managing various blood-related disorders.

  • Mean Corpuscular Volume

  • The Mean Corpuscular Volume test measures the average size of your red blood cells, which carry oxygen through your body. This test tells whether your RBCs are of average size and volume or whether they are bigger or smaller.

  • Mean Corpuscular Hemoglobin

  • An MCH test measures the average amount of hemoglobin in a single red blood cell (RBC). Hemoglobin is an iron-containing protein in RBCs, and its major function is to transport oxygen from the lungs to all body parts. This test provides information about how much oxygen is being delivered to the body by a certain number of RBCs.

  • Mean Corpuscular Hemoglobin Concentration

  • An MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100. 

  • Absolute Leucocyte Count

  • The Absolute Leucocyte Count test measures the total number of white blood cells (leucocytes) in the given volume of blood. It examines different types of white blood cells such as neutrophils, lymphocytes, monocytes, basophils and eosinophils. These cells tell about the status of the immune system and its ability to fight off infections and other conditions like inflammation, allergies, bone marrow disorders etc.

    This further contains

    • Absolute Eosinophil Count
    • Absolute Neutrophil Count
    • Absolute Basophil Count
    • Absolute Lymphocyte Count
    • Absolute Monocyte Count
  • Mean Platelet Volume

  • An MPV test measures the average size of the platelets in your blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days. 

    Platelets help stop bleeding whenever there is an injury or trauma to a tissue or blood vessel by adhering and accumulating at the injury site, and by releasing chemical compounds that stimulate the gathering of more platelets. After these steps, a loose platelet plug is formed at the site of injury, and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or are not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding. 

  • PDW

  • The PDW test reflects variability in platelet size, and is considered a marker of platelet function and activation (clot formation in case of an injury). This marker can give you additional information about your platelets and the cause of a high or low platelet count. Larger platelets are usually younger platelets that have been recently released from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. Higher PDW values reflect a larger range of platelet size, which may result from increased activation, destruction and consumption of platelets.

  • RDW CV

  • The RDW CV test which is part of red cell indices, helps identify characteristics of red blood cells. RDW (red cell distribution width) measures the variations in the sizes of red blood cells, indicating how much they differ from each other in a blood sample. RDW is expressed as RDW-CV, a coefficient of variation. A higher RDW may suggest more variation in red cell sizes, while a lower RDW indicates more uniform red cell sizes.

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CRP (C-Reactive Protein), Quantitative

The CRP test measures the levels of C-reactive protein in your body. This test helps detect the presence of inflammation in the body. It is a non-specific test as it cannot diagnose a condition by itself or determine its exact location or cause. 

CRP is an acute phase reactant protein produced by the liver in response to an inflammation in the body. This inflammation may be due to tissue injury, infection, autoimmune diseases, or cancer. CRP levels are often increased before the onset of other symptoms of inflammation, such as pain, redness, fever, or swelling. These levels fall as the inflammation subsides.

Know more about CRP (C-Reactive Protein), Quantitative

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Malarial Antigen (Vivax & Falciparum) Detection

A Malarial Antigen (Vivax & Falciparum) Detection test measures the presence of specific antigens (proteins) produced by Plasmodium vivax and Plasmodium falciparum parasites. These antigens are released into the blood during the lifecycle of the parasites and serve as a marker for the presence of malaria infection. A Malarial Antigen (Vivax & Falciparum) Detection test targets and identifies these antigens, providing a means of detecting and differentiating between these two common types of malaria parasites.

Know more about Malarial Antigen (Vivax & Falciparum) Detection

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Widal Test (Slide Agglutination)

The Widal Test (Slide Agglutination) helps detect antibodies in the blood against typhoid-causing bacteria called Salmonella typhi.

Know more about Widal Test (Slide Agglutination)

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Peripheral Smear Examination

The Peripheral Smear Examination test is performed to check the characteristics of blood cells including:

  1. Red blood cells (RBCs)
  2. White blood cells (WBCs)
  3. Platelets

By placing the blood sample on a specifically treated slide, these blood components are analyzed under a microscope for their shape, size, and number. Any irregularity in these cells indicates blood disorders or abnormality, the presence of parasites in the blood, etc. This test is also a beneficial tool in monitoring a blood disease or deciding whether a certain medication or therapy is working effectively or not.

Know more about Peripheral Smear Examination

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Chikungunya, IgM

A Chikungunya, IgM test measures the presence of Immunoglobulin M (IgM) antibodies in the blood, specifically targeting the Chikungunya virus. These antibodies are produced in response to a recent Chikungunya infection, helping diagnose the active phase of the disease. 

Know more about Chikungunya, IgM

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Urine R/M (Urine Routine & Microscopy)

The Urine R/M (Urine Routine & Microscopy) test involves gross, chemical, and microscopic evaluation of the urine sample.

  1. Gross examination: It involves visually inspecting the urine sample for color and appearance. Typically, the urine color ranges from colorless or pale yellow to deep amber, depending on the urine’s concentration. Things such as medications, supplements, and some foods such as beetroot can affect the color of your urine. However, unusual urine color can also be a sign of disease.

    In appearance, the urine sample may be clear or cloudy. A clear appearance is indicative of healthy urine. However, the presence of red blood cells, white blood cells, bacteria, etc., may result in cloudy urine, indicating conditions such as dehydration, UTIs, kidney stones, etc. Some other factors, such as sperm and skin cells, may also result in a cloudy appearance but are harmless.

  2. Chemical examination: It examines the chemical nature of the urine sample using special test strips called dipsticks. These test strips are dipped into the urine sample and change color when they come in contact with specific substances. The degree of color change estimates the amount of the substance present. Some common things detected include protein, urine pH, ketones, glucose, specific gravity, blood, bilirubin, nitrites, and urobilinogen.

  3. Microscopic examination: This involves the analysis of the urine sample under the microscope for pus cells, red blood cells, casts, crystals, bacteria, yeast. and other constituents.

Know more about Urine R/M (Urine Routine & Microscopy)

  • Urobilinogen

  • Ketone

  • Nitrite

  • The Nitrite test measures the presence of nitrites in the urine sample. Nitrites are chemicals formed by the conversion of nitrates by certain bacteria. Under normal conditions, urine does not contain nitrites. However, when bacteria that cause urinary tract infections (UTIs) are present, they convert nitrates (which are normally found in the urine) into nitrites. Thus, the presence of nitrites in urine is an indication of a bacterial infection, making the Nitrite test a key tool in diagnosing UTIs.

  • Colour

  • The urine colour test primarily measures the concentration and colour of urine to provide insights into an individual’s  overall health. It assesses hydration status, with clear to light yellow urine indicating good hydration and darker shades suggesting dehydration. It can also detect urinary tract infections (UTIs) through unusual colours like cloudy or reddish urine, signaling the presence of blood or pus. Abnormal urine colours, such as dark brown or amber, may indicate liver conditions like hepatitis or cirrhosis, while pink, red, or brown urine can reveal the presence of blood, signaling kidney issues, trauma, or potential malignancies. The test can reflect dietary influences and supplement intake, with certain foods and vitamins causing colour changes. It can also highlight metabolic disorders, such as porphyria, which may cause purple urine. Additionally, medication effects and potential exposure to toxins can be inferred from changes in urine colour, making this test a comprehensive indicator of overall health and potential underlying conditions.

  • Appearance

  • Specific Gravity

  • Pus Cell

  • Epithelial Cell

  • Casts

  • Crystals

  • Protein Urine

  • Ph for Urine

  • Urine Glucose

  • Yeast

  • The urine yeast test measures the presence of yeast cells in the urine sample. The presence of yeast cells can indicate an infection or an imbalance in the urinary tract's natural microbial environment. Yeast is a type of fungus that naturally resides in small amounts on the skin, in the mouth, and in the intestines. However, when it overgrows, it can cause infections, such as yeast infections in the urinary tract which require medical attention. Therefore this test is crucial for identifying fungal infections, particularly those caused by Candida species, and plays a vital role in guiding appropriate treatment strategies.

  • Red Blood Cells

  • Leucocyte Esterase

  • Blood

  • Bacteria

  • Bilirubin

  • The Bilirubin test measures the levels of bilirubin present in the urine. Bilirubin is a by-product of the breakdown of old red blood cells, processed by the liver. This test is crucial in assessing liver function and detecting liver diseases.

    Normally, the liver converts bilirubin into a form that can be excreted into bile and eventually eliminated from the body. When liver function is impaired, the amount of bilirubin in the urine can change, serving as an important indicator of abnormalities such as liver disease or bile duct blockage.

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Typhidot, IgG & IgM

A Typhidot, IgG & IgM test is an important diagnostic tool to diagnose typhoid fever. This test usually shows the infection within 2-3 days and detects IgM and IgG antibodies, illustrating a recent and a past infection respectively. When Salmonella typhi, the causative bacteria from typhoid, enters the body, your immune system, as a response, releases two types of antibodies (specific proteins), IgM and IgG, against the outer membrane protein of Salmonella typhi.

Know more about Typhidot, IgG & IgM

  • Typhi Dot, IgM

  • The Typhi Dot, IgM test is an important and rapid diagnostic tool to diagnose typhoid fever. This test usually shows the typhoid infection within 2-3 days by detecting IgM antibodies, illustrating an active infection respectively. When Salmonella typhi enters the body, your immune system produces IgM antibodies as the body's first response of defense against the outer membrane protein of Salmonella typhi.

    IgM antibodies are usually present in higher concentrations shortly after infection before gradually decreasing and eventually disappearing. Therefore, a positive IgM test for Salmonella Typhi typically suggests a recent or acute infection.

     

  • Typhi Dot IgG

  • The Typhi Dot IgG test is performed to detect the presence or absence of IgG antibodies against Salmonella typhi, the bacteria that causes typhoid fever. IgG antibodies are the most frequent type of antibody, which are developed at a later stage, usually 2-3 weeks after the virus invades the body and causes the infection, and it remains in the body for life. Thus, IgG antibodies indicate if an individual has been infected with typhoid.

Interpreting Fever Package Extensive (includes Dengue, Malaria, Typhoid & Chikungunya tests) Old results


Interpretations

 

  • Positive Salmonella typhi IgM test suggests recent infection with bacteria Salmonella Typhi causing typhoid fever 

  • Negative Salmonella typhi IgM test usually indicates no infection with the bacteria

 

References

  1. Mahar AF, Allen SJ, Milligan P, Suthumnirund S, Chotpitayasunondh T, Sabchareon A, Coulter JB. Tepid sponging to reduce temperature in febrile children in a tropical climate. Clin Pediatr (Phila). 1994 Apr;33(4):227-31. [Accessed 15 Mar. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/8013170/ External Link
  2. Fernandez C, Beeching NJ. Pyrexia of unknown origin. Clin Med (Lond). 2018 Mar;18(2):170-174. [Accessed 15 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303444/#:~:text=Introduction,1 External Link
  3. Balli S, Shumway KR, Sharan S. Physiology, Fever [Internet]. Treasure Island, Florida: StatPearls Publishing; 2023 Jan. [Accessed 15 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562334/External Link
  4. El-Radhi AS. Fever management: Evidence vs current practice. World J Clin Pediatr. 2012 Dec 8;1(4):29-33. [Accessed 15 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145646/ External Link
  5. Balli S, Shumway KR, Sharan S. Physiology, Fever. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562334/ External Link
  6. El-Radhi AS. Fever in Common Infectious Diseases. Clinical Manual of Fever in Children. 2019 Jan 2:85–140. [Accessed 15 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122655/ External Link
  7. Wrotek S, LeGrand EK, Dzialuk A, Alcock J. Let fever do its job: The meaning of fever in the pandemic era. Evol Med Public Health. 2020 Nov 23;9(1):26-35. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717216/ External Link
  8. Fever [Internet]. Healthdirect; Feb. 2022 [Accessed 15 Mar. 2024]. Available from: https://www.healthdirect.gov.au/fever External Link

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