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Trihexyphenidyl
INFORMATION ABOUT TRIHEXYPHENIDYL
Trihexyphenidyl Uses
How Trihexyphenidyl works
Trihexyphenidyl is an anticholinergic medication. It works by decreasing the activity of a chemical messenger (acetylcholine) in the brain. This improves muscle control and reduces stiffness in Parkinson's disease. It also improves movement disorder (restlessness, involuntary movements or muscle spasm) caused by certain other medicines.
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
11 Jun 2025 | 01:47 PM (UTC)
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Expert advice for Trihexyphenidyl
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
  • It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
  • Inform your doctor if you suffer from  glaucoma or if you have trouble passing urine.
Frequently asked questions for Trihexyphenidyl
No, Trihexyphenidyl is not a narcotic. However, its hallucinogenic and euphoriant properties may make the people abuse its use.
Yes, Trihexyphenidyl may cause drowsiness in some cases. Some people may even experience difficulty in falling asleep. Do not drive or operate heavy machinery when you experience drowsiness or if it causes blurring of vision, dizziness, mild nausea and mental confusion.
Yes, Trihexyphenidyl may cause weight gain. If you are concerned about your weight gain, consult a dietician for diet plan, exercise regularly, and eat a healthy and nutritious diet.
No, Trihexyphenidyl should not be crushed. It should be swallowed as a whole with a glass of water. Consult your doctor if you are not sure about how to take this medicine.
Trihexyphenidyl may be taken before or after meals according to the effects experienced by the patient. If Trihexyphenidyl tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, it may cause induced thirst which can be reduced by peppermint, chewing gum, or water.
You should continue taking Trihexyphenidyl as long as your doctor advises you. In some cases, the use of Trihexyphenidyl may continue indefinitely. Such patients are often kept under careful observation for a longer period of time.
You should not stop taking Trihexyphenidyl without consulting your doctor as your symptoms may get worse. If you feel your dose needs to be lowered, then consult your doctor who will reduce your dose gradually.