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Trazodone
INFORMATION ABOUT TRAZODONE
Trazodone Uses
Trazodone is used in the treatment of depression.
How Trazodone works
Trazodone modulates the level of serotonin in the brain. Serotonin is a chemical messenger in the brain that helps in regulating the mood.
Common side effects of Trazodone
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Vomiting, Dizziness, Confusion, Blurred vision, Headache, Fatigue, Nausea, Sleepiness, Dryness in mouth, Constipation, Edema (swelling), Hypotension (low blood pressure), Fainting, Drowsiness, Nasal congestion (stuffy nose), Weight gain, Weight loss, Pain
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
10 Jun 2025 | 04:53 PM (UTC)
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Expert advice for Trazodone
  • It makes you feel sleepy. Take it in the evening or before you go to bed.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • It may temporarily cause dry mouth and stomach upset. Drink plenty of water and eat more high-fibre foods such as fresh fruit and vegetables.
  • Do not drive or do anything that requires mental focus until you know how Trazodone affects you.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Inform your doctor if you get an erection that lasts longer than four hours while taking this medicine.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Frequently asked questions for Trazodone
Trazodone is not a mono amine oxidase inhibitor/ selective serotonin reuptake inhibitor/ opiate/ barbiturate/ anti cholinergic/ habit forming/ controlled substance
Trazodone is taken for anxiety and depression
Trazodone is not prescribed for sleep or pain relief
Trazodone does not have sulpha in it
Trazodone may cause blood pressure fluctuations. It is not known to cause diarrhea/ feeling high
It is given for the treatment of anxiety and depression. Please consult your doctor for any observed side effects
Trazodone cannot be taken with Nyquil/ Benadryl/ Zoloft/ Cymbalta/ valium/ paxil/ flexeril/ Xanax. Trazodone can be taken with melatonin. Please consult your doctor for any potential interaction.