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Prilocaine Topical



Prilocaine topical is always used in combination with lidocaine as a local anesthetic during superficial minor surgery and medical procedures.

How it works

Prilocaine belongs to a class of medications called as local anaesthetics. It stops the transfer of pain signals to brain and thus numbs the skin/surfaces during surgery or medical procedures.

Common side effects

Application site itching, Application site swelling, Burning sensation, Changes in skin color, Skin rash, Skin redness


No medicine available

Expert advice

  • Inform your doctor if you have a blood disorder/family history of a condition called methemoglobinemia (production of abnormal amount of methemoglobin - a form of haemoglobin, in blood) or other conditions such as glucose-6-phosphate deficiency, any genetical enzyme deficiency, anemia or a skin condition called atopic dermatitis.
  • Protect the area of application from injury as it may continue to be numb for few hours after the procedure. Avoid scratching/ rubbing the area or exposing it to heat/cold until normal sensation resumes.
  • Do not apply cream to larger areas or for longer times than those recommended.
  • Avoid direct contact of cream with your eyes. In case of direct contact, wash your eyes with water immediately and seek immediate medical attention.
  • Inform your doctor if you are using/have recently used any other local anaesthetic or medicines to treat an uneven heart beat or medicines called sulphonamides.
  • Take precaution while driving or operating machinery as prilocaine may make you feel sleepy or may cause temporary loss of sensation and muscle function.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
  • Do not use if you are allergic to prilocaine or any of its ingredients.
  • Do not use if you are allergic to amide-type local anaesthetics.
  • Do not use if you have a condition/family history of methemoglobinemia.
  • Do not use if Infants <12 months who are receiving treatment with methemoglobin-inducing agents.
  • Do not use on Premature babies (gestational age less than 37 weeks).

Frequently asked questions

Prilocaine Topical

Q. Is prilocaine an amide or ester?
Prilocaine is an amide.
Q. What is prilocaine topical used to treat?
Prilocaine topical is used as a local anesthetic to numb the skin/surfaces during superficial minor surgery and medical procedures.
Q. Does prilocaine have epinephrine?
No, Prilocaine does not have epinephrine.
Q. Is prilocaine stronger than lidocaine?
Prilocaine is similar to lidocaine but does not cause vasodilation and has lower CNS toxicity.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)