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Polatuzumab

Written By Dr. Syeda AafiaReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:34 AM (UTC)

Polatuzumab Uses

Polatuzumab is used in the treatment of non-Hodgkin lymphoma (NHL).

How Polatuzumab works

Polatuzumab works by binding with cancer cells and releasing a chemical called monomethyl auristatin E, into the cell causing the cancer cells to die or stop growing.

Common side effects of Polatuzumab

Peripheral neuropathy (tingling and numbness of feet and hand), Nausea, Fatigue, Diarrhea, Constipation, Hair loss, Mucositis, Lymphopenia, Decreased white blood cell count (neutrophils), Increased uric acid level in blood, Anemia (low number of red blood cells), Low blood platelets, Fever, Decreased appetite, Pneumonia
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Expert advice for Polatuzumab

  • Let your doctor know if you are allergic to Polatuzumab, any other medications, or any of the ingredients in Polatuzumab.
  • Inform your doctor all the herbal products you are taking, especially St. John's Wort.
  • It is important to let your doctor know if you have any infections or have or have ever had liver disease.
  • Avoid breastfeeding during your treatment with this medicine and for 2 months after your final dose.