Ocrelizumab
Written By Dr. Swati Mishra
Reviewed By Dr. Rajeev SharmaLast updated 25 Nov 2025 | 09:34 AM (UTC)
Ocrelizumab Uses
Ocrelizumab is used in the treatment of multiple sclerosis (MS) and psoriasis.
How Ocrelizumab works
Ocrelizumab works by targeting a specific protein called CD20, found on the surface of certain B lymphocytes, which are immune cells involved in the damage caused by multiple sclerosis (MS). By binding to CD20, Ocrelizumab eliminates these harmful B cells, reducing the immune attack on the nervous system. This helps control the disease, protect the neurological system, and slow the progression of MS, improving overall outcomes for patients.
Common side effects of Ocrelizumab
Respiratory tract infection, Infusion reaction, Skin infection
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Expert advice for Ocrelizumab
- Always undergo hepatitis B screening before starting treatment. If you have had the virus, your doctor will monitor you closely during and after treatment.
- Patients need to finish all necessary vaccinations at least six weeks before starting Ocrelizumab.
- It is not advised to provide live or live-attenuated vaccines when treating Ocrelizumab or until B-cell recovery.
- Be vigilant about signs of infection, such as fever, chills, or persistent cough, and report them to your doctor immediately. Delay treatment if you have an active infection.
Frequently asked questions for Ocrelizumab
Ocrelizumab is used to treat adults with relapsing or primary progressive forms of multiple sclerosis (MS).
Live vaccines should be avoided during treatment and until your immune system has fully recovered. Complete any necessary vaccinations at least six weeks before starting Ocrelizumab.
Infusion reactions, such as rash, fever, or throat irritation, can occur during or up to 24 hours after infusion. Inform your doctor immediately if you experience any symptoms.
There may be a slightly increased risk of certain cancers, including breast cancer, so regular cancer screenings are recommended as a precaution.