Niraparib
INFORMATION ABOUT NIRAPARIB
Niraparib Uses
How Niraparib works
Niraparib is a selective inhibitor of PARP enzymes, which are involved in repairing damaged DNA in cells. Cancer cells often rely heavily on this repair pathway to survive. It prevents cancer cells from fixing their DNA damage, leading to cell death. Normal cells are less dependent on this pathway, so the medicine mainly affects tumor cells. This action helps slow disease progression and prolong remission in ovarian and related cancers.
Common side effects of Niraparib
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Nausea, Low blood platelets, Anemia (low number of red blood cells), Fatigue, Constipation, Musculoskeletal (bone, muscle or joint) pain, Abdominal pain, Vomiting, Decreased white blood cell count (neutrophils), Decreased appetite, Decreased white blood cell count (lymphocytes), Insomnia (difficulty in sleeping), Headache, Breathlessness, Rash, Diarrhea, High blood pressure, Cough, Dizziness, Acute kidney injury, Urinary tract infection, Decreased magnesium level in blood
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Last updated
27 Nov 2025 | 06:35 AM (UTC)
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Medicine brands for Niraparib
Expert advice for Niraparib
- Dose of Niraparib can be adjusted by the doctor based on the patient’s body weight and platelet count.
- Regularly monitor blood pressure and heart rate; manage hypertension promptly.
- Watch for symptoms of MDS/AML (persistent fatigue, unexplained bruising, infections). Discontinue if confirmed.
- It is important to take Niraparib at the same time daily to maintain stable drug levels.
- If severe adverse events occur (like very low blood counts), the doctor may adjust the dosage.
Frequently asked questions for Niraparib
It is approved as a maintenance treatment after a response to platinum-based chemotherapy.
Hair loss is not very common with Niraparib compared to chemotherapy, but fatigue and blood changes are more likely.
Yes, routine blood tests and blood pressure checks are needed to monitor safety.
Most people can, but tiredness is common, so pacing activities and rest is important.
No, it may harm the unborn baby. Effective contraception is required during treatment.
No, breastfeeding should be avoided during treatment and for some time after stopping.