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Neostigmine
INFORMATION ABOUT NEOSTIGMINE
Neostigmine Uses
Neostigmine is used in the treatment of myasthenia gravis, paralytic ileus, post-operative urinary retention and reversal of effect of skeletal muscle relaxant after surgery.
How Neostigmine works
Neostigmine is a reversible cholinesterase inhibitor. It increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.
Common side effects of Neostigmine
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Nausea, Vomiting, Diarrhea, Excessive salivation, Increased sweating, Stomach cramp
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
10 Apr 2025 | 04:47 AM (UTC)
We provide you with authentic, trustworthy and revelant information
Read our editorial policy
Medicine brands for Neostigmine
Tilstigmin
₹48 to ₹48
Tablets India Limited
1 variant(s)
Myostigmin
₹4 to ₹44
Neon Laboratories Ltd
3 variant(s)
Neotagmin
₹5 to ₹19
Themis Medicare Ltd
2 variant(s)
Stigmerase
₹22 to ₹22
Miracalus Pharma Pvt Ltd
1 variant(s)
Neomine
₹20 to ₹20
Zydus Cadila
1 variant(s)
Tilistigmin
₹46 to ₹46
Tablets India Limited
1 variant(s)
Stimin
₹4 to ₹21
Celon Laboratories Ltd
2 variant(s)
Prostigmin
₹33 to ₹33
Abbott Healthcare Private Limited
1 variant(s)
Stignir
₹107 to ₹107
Nirlife Healthcare
1 variant(s)
Expert advice for Neostigmine
  • Take it with food to avoid an upset stomach.
  • Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
  • It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
  • Do not drink alcohol while taking this medicine as it may worsen the side effects.
  • Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.
  • You have been prescribed Neostigmine for treatment of myasthenia gravis.
  • It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
  • Take it with food to avoid an upset stomach.
  • Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
  • It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
  • Do not drink alcohol while taking this medicine as it may worsen the side effects.
  • Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.
Frequently asked questions for Neostigmine
Neostigmine relieves the symptoms of myasthenia gravis but does not cure it. It does so by reducing and improving muscle weakness. The length of time for which you need to take Neostigmine will depend on your condition. Do not stop taking Neostigmine until and unless advised by your doctor, even if you start feeling better.
Neostigmine takes about 5 to 15 minutes to start working and remains effective for 2-4 hours.
No, Neostigmine is not a steroid. It belongs to cholinesterase inhibitor group of medicines. Neostigmine work by preventing the breakdown of a chemical called acetylcholine.
No, Neostigmine does not cause weight gain. Your weight gain may be due to inactivity related to muscle weakness in myasthenia gravis.
Yes, Neostigmine is safe if used in the dose and duration prescribed by the doctor.
If your symptoms have started reappearing, then it could be due to increased severity of myasthenia gravis or excess dose of Neostigmine. Both the conditions have similar effects, so it becomes very difficult to differentiate between the two. Do not increase the dose on your own and consult your doctor immediately.
No, Neostigmine should not be taken for any type of constipation. However, its use is limited to cases of constipation caused by paralysis of intestine and strictly on prescription by the doctor.
You should seek immediate medical help in case of overdose of Neostigmine.Excess of Neostigmine may cause stomach pain, nausea, vomiting, diarrhea, blurred vision, difficulty in breathing, and excessive sweating, salivation, and weakness. It can even lead to paralysis.
No, there is no evidence of Neostigmine having any abuse potential.
Neostigmine should not be taken by patients who are allergic to it. Patients who are constipated or cannot urinate should avoid its use, unless advised by the doctor. This is because Neostigmine is only used for certain types of urination problems and constipation (e.g. caused by paralysis of intestine).