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Letermovir
INFORMATION ABOUT LETERMOVIR
Letermovir Uses
Letermovir is used in the treatment of herpes labialis, Cytomegalovirus Infection, genital herpes infection, chickenpox, herpes simplex virus infections, eye infections by Herpes simplex virus and chronic hepatitis C virus (HCV) infection.
How Letermovir works
Letermovir is an antiviral medicine. It works by blocking the CMV DNA terminase complex, an enzyme needed for the virus to multiply and spread. It prevents viral replication and helps control CMV infection, reducing the risk of complications, especially in people with weakened immune systems, such as transplant patients.
Common side effects of Letermovir
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Nausea, Diarrhea, Vomiting, Peripheral edema, Cough, Fatigue, Headache, Abdominal pain
CONTENT DETAILS
Written By
Dr. Sakshi Jain
MS, BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
24 Jul 2025 | 08:53 AM (UTC)
We provide you with authentic, trustworthy and revelant information
Read our editorial policy
Medicine brands for Letermovir
Expert advice for Letermovir
  • Always take Letermovir exactly as directed by your doctor. Stopping early or skipping doses can increase the risk of CMV infection recurrence.
  • Letermovir may interact with immunosuppressants, anticoagulants, and other medications. Always inform your doctor about any drugs or supplements you are taking.
  • Patients with liver or kidney disease should use Letermovir with caution. Regular monitoring may be required to adjust the dose safely.
  • Letermovir may cause nausea, headache, or fatigue. Inform your doctor if any side effects persist or worsen.
  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • Drink plenty of water while on treatment with this medicine. This helps to prevent dehydration and kidney damage.
  • If you have genital herpes, use barrier methods (condoms) for contraception and avoid sexual contact while the sores are present.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Frequently asked questions for Letermovir
The duration depends on your condition and risk of CMV infection. Follow your doctor’s instructions carefully.
No, Letermovir does not cure CMV infection. It helps prevent the virus from multiplying, reducing the risk of complications, especially in transplant patients.
If CMV develops resistance, Letermovir may become less effective. Your doctor may recommend alternative treatments or a combination approach.
No. Complete the full course as prescribed by your doctor. Stopping early can lead to viral resistance and the recurrence of infection.
Yes, Letermovir may interact with medications that affect the CYP3A enzyme. Inform your doctor about all medicines you are taking.